Association of Dietary Polyamines with Incident, Sporadic Colorectal Adenomas Open Access

Raji, Kehinde Oladunni (2011)

Permanent URL: https://etd.library.emory.edu/concern/etds/1v53jx42j?locale=en
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Abstract


Abstract

Association of Dietary Polyamines with Incident, Sporadic Colorectal Adenomas
By, Kehinde Oladunni Raji


PURPOSE: To investigate the association of dietary polyamines with risk of incident,
sporadic colorectal adenoma.


METHODS: To investigate the association of dietary polyamines and risk for incident,
sporadic colorectal adenoma, data from the Minnesota Cancer Prevention Research Unit
case-control study were analyzed. The colonoscopy-/community-based case-control study
conducted 1991-1994, enrolled 30-74 year old 564 incident, sporadic, colorectal
adenomas participants, 684 polyp-free controls, and 535 community controls. Diet was
assessed using a 153-food item semi-quantitative Willet food frequency questionnaire
(FFQ). Polyamine exposure was quantified based on responses to the food frequency
questionnaire and a previously published report on the polyamine content of select food
items. Polyamine intakes were categorized according to the quartiles based on the
distribution among the community controls and analyzed using unconditional
multivariate logistic regression.


RESULTS: Polyamine intake was inversely associated with risk for colorectal
adenomas. The odds ratios (OR) for the highest relative to the lowest category of
polyamine intake were 0.57 (95% confidence interval (CI), 0.33 - 1.00; p trend 0.0001)
and 0.76 (CI 0.43 - 1.33; p trend 0.04) in the comparisons with the colonoscopy and
community-based controls, respectively. The inverse associations tended to be stronger
among those with a more positive oxidative balance, no family history of colorectal
neoplasms, and women who did not take hormone replacement therapy, and for smaller
and distal adenomas.


CONCLUSIONS: These findings suggest that higher polyamine intakes may be
associated with lower risk for incident, sporadic colorectal adenomas, perhaps especially
for smaller and distal adenomas.

Association of Dietary Polyamines with Incident, Sporadic Colorectal Adenomas
By
Kehinde Oladunni Raji
B.S
University of California, Los Angeles
2009
Thesis Committee Chair: Roberd Bostick, M.D. M.P.H.
A thesis submitted to the Faculty of the
Rollins School of Public Health of Emory University
in partial fulfillment of the requirements for the degree of
Master of Public Health
in Epidemiology
2011

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