Association of Dietary Polyamines with Incident, Sporadic Colorectal Adenomas Open Access

Abstract

Abstract

Association of Dietary Polyamines with Incident, Sporadic Colorectal Adenomas
By, Kehinde Oladunni Raji

PURPOSE: To investigate the association of dietary polyamines with risk of incident,
sporadic colorectal adenoma.

METHODS: To investigate the association of dietary polyamines and risk for incident,
sporadic colorectal adenoma, data from the Minnesota Cancer Prevention Research Unit
case-control study were analyzed. The colonoscopy-/community-based case-control study
conducted 1991-1994, enrolled 30-74 year old 564 incident, sporadic, colorectal
adenomas participants, 684 polyp-free controls, and 535 community controls. Diet was
assessed using a 153-food item semi-quantitative Willet food frequency questionnaire
(FFQ). Polyamine exposure was quantified based on responses to the food frequency
questionnaire and a previously published report on the polyamine content of select food
items. Polyamine intakes were categorized according to the quartiles based on the
distribution among the community controls and analyzed using unconditional
multivariate logistic regression.

RESULTS: Polyamine intake was inversely associated with risk for colorectal
adenomas. The odds ratios (OR) for the highest relative to the lowest category of
polyamine intake were 0.57 (95% confidence interval (CI), 0.33 - 1.00; p trend 0.0001)
and 0.76 (CI 0.43 - 1.33; p trend 0.04) in the comparisons with the colonoscopy and
community-based controls, respectively. The inverse associations tended to be stronger
among those with a more positive oxidative balance, no family history of colorectal
neoplasms, and women who did not take hormone replacement therapy, and for smaller
and distal adenomas.

CONCLUSIONS: These findings suggest that higher polyamine intakes may be
associated with lower risk for incident, sporadic colorectal adenomas, perhaps especially
for smaller and distal adenomas.

Association of Dietary Polyamines with Incident, Sporadic Colorectal Adenomas
By
Kehinde Oladunni Raji
B.S
University of California, Los Angeles
2009
Thesis Committee Chair: Roberd Bostick, M.D. M.P.H.
A thesis submitted to the Faculty of the
Rollins School of Public Health of Emory University
in partial fulfillment of the requirements for the degree of
Master of Public Health
in Epidemiology
2011

Table of Contents

Table of Contents

About this Master's Thesis

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• Permission granted by the author to include this thesis or dissertation in this repository. All rights reserved by the author. Please contact the author for information regarding the reproduction and use of this thesis or dissertation.

School	Rollins School of Public Health
Department	Epidemiology
Degree	MPH
Submission	Master's Thesis
Language	English
Research Field	Health Sciences, Nutrition Health Sciences, Oncology Health Sciences, Epidemiology
Keyword	Dietary Polyamines Colorectal adenomas Colorectal cancer
Committee Chair / Thesis Advisor	Bostick, Roberd M, Emory University
Partnering Agencies	Emory University schools, faculty or affiliated programs

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