EFFECTS OF CALCIUM AND VITAMIN D SUPPLEMENTATION ON CRYPT MORPHOLOGY IN NORMAL COLON MUCOSA Pubblico
Shen, Huafeng (2011)
Published
Abstract
To investigate the effects of calcium and vitamin D on crypt
morphology (length,
perimeter, and area of crypts) in the normal colorectal mucosa of
sporadic colorectal
adenoma patients, we conducted a pilot, randomized, double-blind,
placebo-controlled
2×2 factorial chemoprevention clinical trial of supplemental
calcium 2,000 mg/day and
vitamin D3 800 IU/day, alone and in combination, versus
placebo over 6 months.
Colorectal crypt length, perimeter, and area in the
normal-appearing rectal mucosa were
quantified by image analysis. The mean crypt length increased by 1%
(p=0.92) in the
calcium group, and decreased by 2% (P = 0.69) and 4% (P = 0.40) in
the vitamin D and
calcium plus vitamin D groups, respectively, relative to the
placebo group. The mean
crypt perimeter decreased by 2% (P = 0.70) and 4% (P = 0.40) in the
vitamin D and
calcium plus vitamin D groups, respectively, relative to the
placebo group, but did not
change appreciably in the calcium group. The mean crypt area
decreased by 2% (P =
0.74), 5% (P = 0.41) and 7% (P = 0.30) in the calcium, vitamin D
and calcium plus
vitamin D groups, respectively, relative to the placebo group.
These results indicate that
calcium and/or vitamin D3 supplementation does not change the crypt
morphology
(length, perimeter, and area of crypts) in the normal human
colorectal epithelium of
sporadic adenoma patients.
Table of Contents
TABLE OF CONTENTS
CHAPTER
I..............................................................................................1
Descriptive
Epidemiology..........................................................................1
Colorectal
Carcinogenesis.........................................................................2
Environmental Factors in Colorectal Cancer
................................................3
Calcium, Vitamin D, and Colorectal Cancer
Risk.............................................4
Surrogate End-Point Biomarkers (SEBs) in Colorectal
Cancer...........................8
Crypt Morphology and Colorectal
Cancer.....................................................9
CHAPTER
II.............................................................................................12
ABSTRACT............................................................................................12
INTRODUCTION......................................................................................13
METHODS.............................................................................................14
RESULTS..............................................................................................19
DISCUSSION..........................................................................................21
CHAPTER
III............................................................................................26
REFERENCES............................................................................................27
TABLES AND
FIGURES................................................................................33
APPENDIX...............................................................................................39
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