Association between Prenatal Exposure to Polyfluoroalykl Compounds and Bone Health in British Girls 公开

Abstract

BACKGROUND: Endocrine disrupting chemicals (EDCs), such as polyfluoroalkyl compounds (PFCs), are exposures that disrupt signaling pathways during fetal development through alteration of hormonal functions (1). Previous research suggests a possible inverse relationship between various EDC exposures and bone health (2-5).

OBJECTIVES: We explored associations between prenatal serum concentrations of common PFCs, such as perfuorootane sulfonate (PFOS), perfluorooctane (PFOA), perfluorohexane sulfonate (PFHxS), and perfluorononanoic acid (PFNA), with bone health. We used total body and total body less head bone mineral density (BMD), bone mineral content (BMC), bone area (BA), and area adjusted BMC (ABMC) to measure bone health.

METHODS: We studied a sample of 357 mother-daughter dyads participating in the Avon Longitudinal Study of Parents and Children (ALSPAC). Maternal serum samples were obtained in 1991-1992 during pregnancy. Data on bone outcomes were obtained using whole body dual-energy x-ray absorptiometry (DXA) scans during clinic visits at age 9. We explored associations between prenatal PFC concentrations and bone outcomes at age 9 based on multivariate adjusted models.

RESULTS: PFOS (mean: 21.64 ng/mL), PFOA (mean: 2.05 ng/mL), PFHxS (mean: 1.34 ng/mL), and PFNA (mean: 0.68 ng/mL) were detected in 100% of samples. After controlling for confounders, a one ng/mL increase in PFOS, decreased total body BMC by1.944g (SE=0.975, p=0.05) and total body BA decreased by 1.799 cm2 (SE=0.833, p=0.03). One ng/mL increase in PFOS was also associated with a 1.811 cm2 (SE=0.817, p=0.03) decrease in total body less head BMC after controlling for the same confounders. PFOA was significantly inversely associated with total body less head BA (β=-8.577, SE=4.319, p=0.05).

CONCLUSIONS: We found significant associations between maternal exposure to PFCs and daughter's bone health outcomes at age 9, suggesting that intrauterine PFC exposures have a prolonged negative effect on the bone health of offspring.

Table of Contents

I. Introduction 1 II. Methods 3 III. Results 6 IV. Discussion 7 V. References 11 VI. Tables 14

About this Master's Thesis

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School	Rollins School of Public Health
Department	Epidemiology
Degree	MPH
Submission	Master's Thesis
Language	English
Research Field	Health Sciences, Public Health Environmental Sciences Health Sciences, Epidemiology
关键词	polyfluoroalykl compounds bone health endocrine disrupting chemicals
Committee Chair / Thesis Advisor	Hartman, Terry, Emory University
Partnering Agencies	University, college or educational institution (other than Emory) CDC

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