Coffee and Tea Intake and Risk of Incident, Sporadic Colorectal Adenomas Open Access

Abstract

Background: Coffee and tea are commonly consumed beverages that contain several bioactive compounds, and have been suggested to influence colorectal carcinogenesis. However, the findings from epidemiologic studies are inconsistent.

Objective: The current study aimed at investigating the association of coffee and tea intake with risk of incident, sporadic colorectal adenomas (CRA).

Methods: We analyzed data from a case-control study conducted in the Minneapolis metropolitan area between 1991 and 1994. Participants were residents aged 30-74 years and with no personal history of colorectal neoplasms, including 564 cases, 1202 endoscopy-negative controls and 535 frequency-matched community controls. The consumption of caffeinated coffee, decaffeinated coffee and tea was analyzed as categorical and continuous variables, and the associations were estimated using unconditional logistic regression models.

Results: High intake of caffeinated coffee was associated with high risk of CRA when comparing cases with endoscopy controls (4-6 cups/day vs. nondrinkers OR=1.87 95% CI: 1.35-2.59, P for trend<0.01), but not with community controls (4-6 cups/day vs. nondrinkers OR=1.37, 95% CI: 0.94-1.98, P for trend=0.17). Decaffeinated coffee was associated with a higher risk of CRA in the comparison of cases with both endoscopy controls (2-6 cups/day vs. nondrinkers OR=1.53, 95% CI: 1.13-2.08, P for trend<0.01) and community controls (2-6 cups/day vs. nondrinkers OR=1.44, 95% CI: 1.01-2.04, P for trend=0.04). These associations were suggestively stronger for people who were overweight or obese, and who had multiple adenomas or tubular adenomas. Tea was not associated with risk of CRA.

Conclusion: Our findings suggest that high consumption of caffeinated or decaffeinated coffee may increase risk of CRA; and intake of tea is not associated with risk of CRA.

Table of Contents

Background.........................................................................................................................1

Epidemiology of Colorectal Adenoma (CRA) and Colorectal Cancer (CRC)................................1

Risk factors for Colorectal Neoplasms....................................................................................2

Coffee,Tea and Colorectal Carcinogenesis..............................................................................3

Methods..............................................................................................................................6

Study population and data collection.....................................................................................6

Statistical analysis................................................................................................................8

Results.................................................................................................................................9

Discussion...........................................................................................................................12

Public Health Implication.....................................................................................................18

Appendices..........................................................................................................................20

Table 1: Selected characteristics of participants in the Minnesota CPRU case-control study of incident, sporadic CRA (N=2301)20

Table 2: Age- and sex- and multivariable-adjusted associations of coffee and tea intake with incident, sporadic CRA in the Minnesota CPRU case-control study, 1991-1994................................................................................................22

Table 3: Multivariable-adjusted association of coffee and tea intake with incident, sporadic CRA by selected risk factors in the Minnesota23

Table 4: Multivariable-adjusted association of coffee and tea intake with incident, sporadic colorectal adenomas by adenoma characteristics in the Minnesota CPRU case-control study, 1991-1994............................................................26

References:......................................................................................................................... 28

About this Master's Thesis

Rights statement

• Permission granted by the author to include this thesis or dissertation in this repository. All rights reserved by the author. Please contact the author for information regarding the reproduction and use of this thesis or dissertation.

School	Rollins School of Public Health
Department	Epidemiology
Degree	MPH
Submission	Master's Thesis
Language	English
Research Field	Health Sciences, Epidemiology
Keyword	Colorectal carcinogenesis Coffee Tea Colorectal adenoma
Committee Chair / Thesis Advisor	Fedirko, Veronika, Emory University

Last modified

Primary PDF

Thumbnail	Title	Date Uploaded	Actions
	Coffee and Tea Intake and Risk of Incident, Sporadic Colorectal Adenomas ()	2018-08-28 11:59:23 -0400	Press to Select an action Download

Supplemental Files

Thumbnail	Title	Date Uploaded	Actions