Coffee and Tea Intake and Risk of Incident, Sporadic Colorectal Adenomas Open Access

Guo, Junjie (2016)

Permanent URL: https://etd.library.emory.edu/concern/etds/02870w18r?locale=en
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Abstract

Background: Coffee and tea are commonly consumed beverages that contain several bioactive compounds, and have been suggested to influence colorectal carcinogenesis. However, the findings from epidemiologic studies are inconsistent.

Objective: The current study aimed at investigating the association of coffee and tea intake with risk of incident, sporadic colorectal adenomas (CRA).

Methods: We analyzed data from a case-control study conducted in the Minneapolis metropolitan area between 1991 and 1994. Participants were residents aged 30-74 years and with no personal history of colorectal neoplasms, including 564 cases, 1202 endoscopy-negative controls and 535 frequency-matched community controls. The consumption of caffeinated coffee, decaffeinated coffee and tea was analyzed as categorical and continuous variables, and the associations were estimated using unconditional logistic regression models.

Results: High intake of caffeinated coffee was associated with high risk of CRA when comparing cases with endoscopy controls (4-6 cups/day vs. nondrinkers OR=1.87 95% CI: 1.35-2.59, P for trend<0.01), but not with community controls (4-6 cups/day vs. nondrinkers OR=1.37, 95% CI: 0.94-1.98, P for trend=0.17). Decaffeinated coffee was associated with a higher risk of CRA in the comparison of cases with both endoscopy controls (2-6 cups/day vs. nondrinkers OR=1.53, 95% CI: 1.13-2.08, P for trend<0.01) and community controls (2-6 cups/day vs. nondrinkers OR=1.44, 95% CI: 1.01-2.04, P for trend=0.04). These associations were suggestively stronger for people who were overweight or obese, and who had multiple adenomas or tubular adenomas. Tea was not associated with risk of CRA.

Conclusion: Our findings suggest that high consumption of caffeinated or decaffeinated coffee may increase risk of CRA; and intake of tea is not associated with risk of CRA.

Table of Contents

Background......................................................................................................................... 1

Epidemiology of Colorectal Adenoma (CRA) and Colorectal Cancer (CRC).............. 1

Risk factors for Colorectal Neoplasms............................................................................. 2

Coffee,Tea and Colorectal Carcinogenesis...................................................................... 3

Methods................................................................................................................................ 6

Study population and data collection............................................................................... 6

Statistical analysis............................................................................................................ 8

Results.................................................................................................................................. 9

Discussion........................................................................................................................... 12

Public Health Implication.................................................................................................. 18

Appendices......................................................................................................................... 20

Table 1: Selected characteristics of participants in the Minnesota CPRU case-control study of incident, sporadic CRA (N=2301)20

Table 2: Age- and sex- and multivariable-adjusted associations of coffee and tea intake with incident, sporadic CRA in the Minnesota CPRU case-control study, 1991-1994........................................................................................................... 22

Table 3: Multivariable-adjusted association of coffee and tea intake with incident, sporadic CRA by selected risk factors in the Minnesota23

Table 4: Multivariable-adjusted association of coffee and tea intake with incident, sporadic colorectal adenomas by adenoma characteristics in the Minnesota CPRU case-control study, 1991-1994.......................................................... 26

References:......................................................................................................................... 28

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