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SYNTHETIC AND QUANTUM-CHEMICAL EXPLORATION OF THE SELECTIVITY OF
DONOR/ACCEPTOR-SUBSTITUTED METALLOCARBENOIDS
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Synthetic Studies for Heterocycle Synthesis Part I:
Intra/intermolecular Olefin Diamination for the Stereoselective
Synthesis of 3-Aminopiperidines Part II: Total Synthesis of
Malagashanine and Synthetic Studies Toward Related Alkaloids
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Ligand Design Strategies for Regulating Small Molecule Binding and
Reactivity at Transition Metal Centers
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Expanding the Scope of Donor/Acceptor Rhodium-Carbene Chemistry
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EXPLORATION OF HIGH SYMMETRY DIRHODIUM CATALYSTS AND THE REACTION
OF DONOR/ACCEPTOR CARBENOIDS WITH ALCOHOLS
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TRANSITION METAL CATALYZED STEREOSELECTIVE TRANSFORMATIONS OF
ALKYNES AND DONOR/ACCEPTOR CARBENOIDS
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Design, Synthesis, and Utilization of Iridium(III)
Bis(oxazolinyl)phenyl and Iridium(III) Bis(imidazolinyl)phenyl
Complexes for Catalytic Enantioselective Atom Transfer C-H
Functionalization
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Investigation and Modeling of Binding Modes of Novel Small-Molecule
Nox2 Inhibitors
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I. Self-Assembly of Thioether-Modified Cationic Surfactants
II. Electrostatic Binding among Equilibrating 2-D and 3-D
Self-Assemblies
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Chapter 1. Total synthesis of Fumonisin B1 Chapter 2.
Synthesis of Unnatural Sphingolipids: 1-deoxy-5-hydroxysphinganine
and its diastereomers Chapter 3. Development of Methodology:
Synthesis of cis- and trans-homoallylic alcohols
Chapter 4. Human Milk Oligosaccharides: Synthesis of Natural and
Unnatural oligomers
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Design, Synthesis, and Biological Evaluation of Subunit
Selective N-Methyl-D-Aspartate Receptor Modulators
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Directed Evolution and Computational Design of Nucleoside Analog
Kinases
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I. A New Approach to the Synthesis of a Key 5-Oxo-Pyridinyl
Molybdenum Scaffold. II. Oxidative Demetalation of
η3-Allylmolybdenum Complexes with an Oxygen
Nucleophile; Application to the Synthesis of (+)-Isofebrifugine
Analogs
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I. Development of a passive sampler and static sampling chamber
to measure personal exposure to gaseous PAHs. II. Method
development for determination of current-use and persistent
pesticides in cow milk, human breast milk, baby formulas, and human
serum using gas chromatography tandem mass spectrometry.
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Orientation and Vibrational Dynamics of Rhenium Bipyridyl
CO2-Reduction Catalysts on Model Electrode
Surfaces
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Efficient implementations of quantum chemistry methods for strongly
correlated electrons
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Synthesis of protein-based polymers with the potential to form
physically and covalently cross-linked networks
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Simulations of Lipid Sorting Effects near Transmembrane
Peptide
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Amyloid Conformational Diversity Accessed By Truncations of a
Native Protein Fold
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Degradation of pesticides in food and beverages: Implications for
risk assessment
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Coordination Mode Versatility and Intramolecular Bond Activation
in Metal Complexes Supported by a Family of Tris(amidato)amine
Ligands
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Identification of Small Molecule Inhibitors of I-κB
Kinase
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Expanding the Scope of Donor/Acceptor Carbenes and the Synthesis of
Novel Therapeutic Agents for Cocaine Abuse
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Creation of Tubular α− Helical Assemblies Through
Seven-Helix Coiled Coils
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Part I: Synthesis of Cyclobutyl
Nucleoside Analogs That Mimic AZT for Inhibition of the K65R HIV-1
Reverse Transcriptase Mutant
Part II: Synthesis and Evaluation of
Truncated Triptolide Analogs to Suppress Chronic Inflammation
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Quantum Confined Semiconductor Nanocrystals for Efficient Charge
Separation and Solar-to-fuel Conversion
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Modular Synthesis of Polyketide Natural Products: Synthesis of
the C9-C27 Degradation Product of Aflastatin A and Total Synthesis
of Fostriecin
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Development of a Copper Catalyzed Aminoacetoxylation Reaction of
Olefins, Development of an Intermolecular and Diastereoselective
Iminium Cascade Reaction and Studies Towards the Synthesis of a
Malagasy Alkaloid
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TARGETING MIXED LINEAGE LEUKEMIA AS ANTICANCER THERAPY FOR
INFANTILE ACUTE LYMPHOBLASTIC LEUKEMIA THROUGH THE SYNTHESIS OF
NOVEL COMPOUNDS
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Recombinant Site Specific Labeling of Proteins with IR Probes
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Stereocontrolled Synthesis of Ketones bearing Stereogenic Centers
by Desulfitative Cross-Coupling of Thiol Esters and Organostannanes
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Chiral Materials and Water Oxidation Catalysts from
Transition-Metal-Substituted Polyoxometalates
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Dynamics Calculations of Several Atmospheric Reactions on Global
Potential Energy Surfaces
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Chapter 1: The development of a model system for the B-ring of
brevenal and methods for the formation of seven-membered rings.
Chapter 2: Iterative alkyne-epoxide cross-couplings toward the
total synthesis of PM toxin A. Chapter 3: The development of
synthons for 1,3-dimethylallylation of aldehydes.
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Enzyme Engineering
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Synthesis of 2'-Fluoro-2',3'-Dideoxynucleosides as Inhibitors of
Hepatitis C Virus RNA-Dependent RNA Polymerase; Synthesis of
Cyclobutyl Phosphonate and Phosphoramidate Prodrugs for Inhibition
of HIV Reverse Transcriptase
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Nanoscale Tools to Expand the Biophysical Understanding of
Epidermal Growth Factor Receptor Function
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Programmed Self-assembly of Coiled-coil Peptides
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Synthesis and Reactivity of Transition Metal Complexes Supported by
a Neutral Tetraamine Ligand Containing N,N'-dimethylaniline
Units
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Gold(III) Complexes as Potential Anticancer Metallotherapeutics
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In Situ Kinetic Studies of Reactions Involving Dirhodium(II)
Donor/Acceptor Carbenes
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Globin Coupled Sensor Signaling in P. carotovorum: A Model of
Biofilm Regulation through Oligomerization of Diguanylate Cyclases
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Investigation of C-H Bond Oxidation Reactions: I. Asymmetric
Amination of C-H Bonds Using Ruthenium(II) Catalysts II.
Investigation of Structural Determinants of Monoamine Oxidase B
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Use of Receptor-Based Drug Design and Applications in the Study
of finding antagonists for MD-2/TLR4, GLP and CXCR4
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Explorations of Metallocarbene and Metallonitrene Reactive
Intermediate Chemistry for the Development of Synthetically Useful
New Reactions
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Progress Toward the Total Synthesis of PM-toxin A And Future
Development of Mild Lewis Acid Activated Alkynylation of Epoxides
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Interfacial Electron Transfer Dynamics between Organic Molecular
Adsorbates and Semiconductor Nanoparticles
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From Aptamer to Riboswitch: High-throughput Screens and Selections
for the Identification and Creation of Synthetic Riboswitches
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Biomaterial Design: Human Tropoelastin
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Rhodium(II)-Catalyzed Asymmetric Transformations and Their
Applications in The Development of Novel CNS Drug Candidates
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Theoretical Studies of Unusual Molecular Vibrational
Dynamics
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Development of Monocarbonyl Curcumin Analogues Towards Treating
Tuberculosis and Cancer
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SYNTHESIS OF CYCLOPROPANES AND DIHYDROFURANS BY METAL CARBENOID
REACTIONS
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Immobilization of Polyoxometalates for Electrochemical Water
Oxidation
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Part I: Design, Synthesis, and Biological Activity of NMDA
Receptor Antagonists
Part II: Design and Synthesis of Measles Virus Inhibitors
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Conformational evolution in amyloid self-assembly
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Validation of Receptor-Based Drug Design and Applications in the
Study of IKKs, Truncated Taxane and LRH-1
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Rhodium Alkenylcarbenes: Novel Reactivity and Precursors
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Charge Separation Dynamics between Semiconductor Nanoparticles and
Molecular Adsorbates
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Exploring Catalytic Properties of Polyoxometalates in Aerobic
Decontamination and Water Oxidation
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Investigations Into the Design of Electronically Responsive Ligands
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CO2 Reduction Catalyzed by Mercaptopteridine
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Innocent and Non-innocent Countercation Interactions in Transition
Metal Oxidation Catalysts
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Mild Amide and Peptide Constructions by the Condensation of
O-Silylthionoesters with Amines and Metal Mediated Cross-Coupling
Reactions for Carbon-Carbon Bond Formation
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Design, Synthesis, and Biological Evaluation of Subunit-Selective
N-Methyl-D-Aspartate Receptor Antagonists
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Spectroscopic studies of molecules that challenge computational
chemistry
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Development of High Throughput Screening Methods to Identify
Potential Therapeutic Oxygen Carriers
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Polyoxometalates as Water Oxidation Catalysts and Their Use in
Light-Driven Water Splitting
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Electron Transfer Kinetics in a Triad Photo-anode for Light-driven
Water-splitting
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ASYMMETRIC REACTIONS OF DONOR/ACCEPTOR RHODIUM CARBENOIDS: FROM
FORMAL CYCLOADDITIONS TO C-H INSERTION
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Organometallic Enantiomeric Scaffolds in the Synthesis of
Alkaloids: I. Homo-SN2´-like Reaction/Annulative Demetallation
and the Application in the Synthesis of (+)-Isofebrifugine II.
Uncatalyzed Electrophilic C-C Bond Forming Reactions of Pyranyl and
Pyridinyl Molybdenum Complexes
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Design, Synthesis, and Biologic Evaluation of
Tetrahydroisoquinoline-Based CXCR4 Modulators
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Gas Phase Molecular Spectroscopy: Electronic Spectroscopy of
Combustion Intermediates, Chlorine Azide Kinetics, and
Rovibrational Energy Transfer in Acetylene
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Chiral dirhodium catalysts design, synthesis and application in
asymmetric carbenoid transformations and silver-catalysis of
vinylogous fluorination
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The Effect of Methylene Spacers on the Spectral, Electrochemical,
Structural, and Photophysical Properties and Electron Injection
Dynamics of Bis(4,4'-disubstituted-2,2'- bipyridyl) Ruthenium(II)
Dye Analogues and The Effect of Alkali Metal Ions on the Structure
and Spectroscopy of a Tripodal Co(II) Complex
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Design, Synthesis, and Biological Evaluation of Subunit-Selective
N-Methyl-D-Aspartate Receptor Modulators
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Single Quantum Dot Electron Transfer Dynamics
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High Resolution THz Spectroscopy of Astrophysically Relevant Ions
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Application of fluorescent nucleoside analogs in direct evolution
of Drosophila melanogaster deoxyribonucleoside kinase
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Single- and Double-Component Atomistic Models of
Phosphatidylcholine Lipid Bilayers in the Gel and Liquid
Crystalline Phases
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RHODIUM CATALYZED ASYMMETRIC TRANSFORMATIONS OF VINYLCARBENOIDS
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Development of a Novel Cascade Cyclization Reaction and its
Application Towards the Total Synthesis of Malagashanine: A
Chloroquine Efflux Inhibitor
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Design and Development of Novel Methods for C-H Functionalization
for Amination and C-C Bond Formation
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Muti-site specific incorporation of non-canonical amino acids for
biomaterials design
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[5+2] Cycloadditions to Form Oxobicyclo[3.2.1]octanes
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CYCLOADDITIONS AND YLIDE CHEMISTRY OF DONOR/ACCEPTOR- SUBSTITUTED
CARBENES FROM THERMAL DECOMPOSITION OF ARYLDIAZOCARBONYL COMPOUNDS
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Ring Chain Isomerism: Ligands for Mediating Two-Electron
Reactivity with First-Row Transition Metals
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Generating designer enzymes for therapeutic and industrial
applications
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THE BROAD-HOST-RANGE PATHOGENESIS OF AGROBACTERIUM
TUMEFACIENS: SUCCESSFUL COUPLING THE MOTIONS AND DOMAIN
INTERACTIONS WITHIN VIRA TO INTEGRATE SIGNAL SENSING
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Navigating the Roads to Drug Discovery: Part 1: Design, Synthesis,
and Biological Evaluation of a Novel Class of Allosteric Modulators
of N-Methyl-D-Aspartate Receptor Function Part 2: Discovery of
Novel Tetrahydroisoquinoline (THIQ)-Based CXCR4 Antagonists and
Conformational Analysis of Structurally Similar CXCR4 Antagonists
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Polyoxometalates in Artificial Photosynthesis: Development of
Chromophores and Water Oxidation Catalysts
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Photo-induced Charge Carrier Dynamics in Artificial Atoms,
Molecules, and Solids Studied by Transient Absorption Spectroscopy
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Spectroscopic Study of Kinetic Processes Occurring upon
Photoexcitation of Alkali Metal Vapors Mixed with Rare Gases
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Calculations of Prebiotic Molecules Formed from O(1D) Insertion
Reactions
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Design, Synthesis and Biological Evaluation of C4-C9 Bridged
Epothilone Analogs
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Transition-metal-substituted polyoxometalates as water oxidation
catalysts
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Engineering kinases for dual thymidine and thymidylate kinase
activity
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A menthol derived synthon for preparing homoallylic alcohols
bearing three contiguous elements of stereochemistry and Progress
towards a synthon with two centers of reactivity for the allylation
of two different aldehydes
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Elucidating the Biophysical Mechanisms of Notch Activation
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Computer-Assisted Drug Discovery Part I: Design, Development,
Validation and Application of FRESH, a Novel In-Silico
High-throughput Screening Program Part II: Monocarbonyl Curcumin
Analogues: Heterocyclic Pleiotropic Kinase Inhibitors that Mediate
Anticancer Properties Part III: Development of 2nd Generation
NAMFIS Software Program by Java
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