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Ancestral Sequence Reconstruction as a Lead Optimization Approach in Gene Therapy Drug Development
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Advancing novel ligand-based cellular therapies for the treatment of pediatric acute myeloid leukemia
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Discovery of Novel Natural Products to Combat Multidrug Resistant Bacteria and Fungi
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Proteomic and transcriptomic signatures of microglia-derived extracellular vesicles and extension into in vivo systems.
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The nature of co-infection during outbreaks of infectious disease
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A Ventral Hippocampal to Lateral Septum Pathway Regulates Social Novelty- Familiarity Preference
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Identifying HELZ as a Novel DNA Double-Strand Break Repair Protein
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A Multi-Omic Approach to Define Molecular Changes in Human Tauopathy
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Striatal melanocortin-4 receptor control of action flexibility
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Defining the mechanism of substrate recognition by the tRNA methyltransferase Trm10
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Mechanisms of plasticity in sympathetic preganglionic and postganglionic neurons of the chick embryo
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Substrate-dependent effects of myeloperoxidase-derived oxidants on the metabolome and transcriptome of human airway epithelial cells
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Structural and Functional Characterization of the Asprosin and Protein Tyrosine Phosphatase Receptor Type D (PTPRD) Interaction
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Assessing the efficacy and feasibility of a prophylactic treatment for chytridiomycosis
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Characterizing and targeting inflammation in COVID-19 using a rhesus macaque model of SARS-CoV-2 infection
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Functionality of placental 5-hydroxymethylcytosine and associations with birthweight
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Proteomic profiling of neuronal and microglial cells using TurboID in inflammatory and homeostatic states for extension into in vivo systems.
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THE RNA EXOSOME: IMPLICATIONS FOR GENE EXPRESSION REGULATION AND NEUROLOGICAL PATHOLOGY
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Botanicals As A Source Of Novel Therapeutics For Infectious Diseases
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in situ differentiation of B cells cross-reactive to Epstein-Barr virus and autoantigens in hidradenitis suppurativa
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The microbial symbiont of an agricultural insect pest affects pathogen vectoring across scales
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Discovery of SARS-CoV-2 Antivirals from Zoonotic Peptides and Repurposed Drugs
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Astrocytes of the primate: form and function in health and disease
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Adaptations to Tonic T cell Receptor Signaling in Naive T Cells
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Inter- and Intra-specific Interactions of Staphylococcus aureus Modeling Cystic Fibrosis Infection
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MERTK inhibition selectively activates a DC – T-cell axis to provide anti-leukemia immunity
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Divergence from the human astrocyte developmental trajectory in glioblastoma
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Locus coeruleus physiology in physiology in Alzheimer’s disease
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AN INVESTIGATION OF SPINAL ECTOPIC EPILEPTIFORM ACTIVITY
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The Yes-Associated Protein (YAP) promotes resistance to anti-GD2 immunotherapy in neuroblastoma through downregulation of ST8SIA1
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Elucidating the Lysosomal Function of Granulins
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Investigating the mechanisms of a lipoprotein chaperone essential to outer membrane biogenesis
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From individuals to communities: investigating the snail-schistosome system across scales
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The ADGRB1 receptor (BAI1): A key player in phagocytosis, brain development, and neurological disease
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Parallel evolution of alternate morphotypes of Chryseobacterium gleum during experimental evolution with Caenorhabditis elegans
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Evaluating the Sustainability of Azolla-Rice Farming in Northern Senegal
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The development and functional testing of cellular therapies against protein tyrosine kinase 7 (PTK7) to treat high-risk neuroblastoma
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Integrated Proteomics to Understand the Role of Neuritin (NRN1) as a mediator of Cognitive Resilience to Alzheimer’s Disease
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Siglec-15 is required for evasion of immune response in acute lymphoblastic leukemia
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Understanding the Functional Contribution of Heme to the Progression of Atherosclerosis in Beta Thalassemia
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Local ecdysone synthesis in a wounded epithelium sustains developmental delay and promotes regeneration in Drosophila
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Intoxicating Interactions: The Impacts of Chronic Alcohol Use and SARS-CoV-2 Infection on Airway Epithelial Cells
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Neurobehavioral Processes Shaping Infant Development in the First 6 Postnatal Months and Emerging Differences in Autism
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Studying the combination of CAR T cells and ICI for treatment of Melanoma
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Ectopic transcription due to inappropriately inherited histone methylation may interfere with the ongoing function of terminally differentiated cells
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Investigating the Role for Y-Box Binding Protein 1 in Medulloblastoma Radiation Resistance and Post-transcriptional Regulation of Migration and Metastasis
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The Mitochondrial Electron Transport Chain Regulates Expression and Secretion of the Lipoprotein APOE
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Horizontal Transfer of Antibiotic Resistance in Streptococcus pneumoniae
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Strategies for engineering γδ T cells to treat pediatric cancers
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RGS14 protects against seizure-induced mitochondrial oxidative stress and pathology in the hippocampus
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Goals Unhindered: How spatially selective disinhibition drives new important memories.
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Identification of Modifying Genes Associated with Fragile X Disorders Using TWAS
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From species-wide to single colony: Multi-scale analysis of the ubiquitous pathogen Staphylococcus aureus
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Succinyl-CoA ligase ADP-forming subunit beta promotes stress granule assembly to regulate redox and drive cancer metastasis
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Isoform-selective PI3K inhibition confers resilience to cocaine-elicited behaviors
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Proinflammatory mechanisms of streptococcal pyrogenic exotoxins
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Oppressive Systems and Risk for PTSD in Minoritized Communities
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Contribution of the direct and indirect basal ganglia pathways to the pathophysiology of dystonia
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Exploring The Phenotypic Effects of Toll Signaling Pathways In Tumor Progression in EGFR-driven Glioblastoma Models
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Noradrenergic dysfunction in neurodegenerative disease
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Multisensory Flicker Modulates Widespread Brain Networks and Reduces Interictal Epileptiform Discharges in Humans
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Characterization of HIV-1 antisense RNA and enhanced transcription with interference of LEDGF/p75-directed integration
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A 3D Co-culture Spheroid Screening System for Studying the Malignant Transformation of Ductal Carcinoma in situ to Invasive Ductal Carcinoma
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Evaluating Efficacy of CD26+ CAR T Cells in an Orthotopic, Immunocompetent Mouse Model of Pancreatic Ductal Adenocarcinoma
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The Role of Shear-Sensitive Protein Heart of Glass Homolog 1 (HEG1) in Endothelial Biology and Atherosclerosis
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Sink or Swim: Mechanisms of dNTP Pool Elevation by Lentiviruses and Cancer
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Ten-Eleven Translocation Proteins-Mediated Epigenetic Regulation in Alzheimer’s Disease
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Widefield cortical voltage imaging reveals fast network activity dynamics during locomotion, reaching, and decision making
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Immune Modulatory Strategies to Prevent Costimulation Blockade Resistant Rejection
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Development and characterization of synthetic modulators of nuclear receptor LRH-1: Driving divergent signaling using a common molecular scaffold
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GluN2B-Selective NMDA Receptor Negative Allosteric Modulation as a Treatment for Chronic Pain and Opioid Tolerance
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Characterizing Human-Disease Mutations in the Essential RNA Exosome with the Budding Yeast Model System
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CD8 T Cell Differentiation during Viral Infection
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Uncovering the contribution of rare genetic variants in orofacial clefts
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Neural codes underlying memory and flexible navigation in health and Alzheimer’s disease
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Characterizing Infection of B Cells with Wild-type and Vaccine Strains of Measles Virus
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Mechanisms of HIV Pathogenesis, Persistence and Control in SIV-infected Rhesus Macaques
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A Profiling of DNA Modifications in Neurodegenerative and Neuropsychiatric Disorders
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Quantifying animal social behavior during pair bond formation
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Synaptic and Cellular Evaluation of NMDA Receptors in Health and Disease
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Targeting TIGIT to alleviate costimulation blockade-resistant rejection: Analysis of the effects of TIGIT agonism on regulatory and memory T cells during allograft rejection
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Coinfection Dynamics and Host Restriction in Influenza A Virus Infection
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Imatinib mesylate as a host directed therapeutic for mycobacterial infection
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Control of Ankle Dorsiflexion in Persons with Spinal Cord Injury: Neurophysiology and Neuromodulation via Afferent Stimulation
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Overcoming Spatiotemporal Trade-offs in Calcium Imaging Using Deep Learning-based Dynamics Modeling
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Measuring and Understanding Muscular Control of Vocal Production in Songbirds (The neuromuscular dynamics of avian karaoke)
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Characterizing Interactions Between Descending Cortical and Spinal Sensorimotor Circuits Across the Adult Lifespan and their Implications for Balance Control
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Unraveling Autoinhibition and Activation Mechanisms of the von Willebrand Factor A1 Domain
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Investigation of the factors that regulate sporulation initiation in Clostridioides difficile
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Differential regulation of Peroxisome Proliferator Activating Receptors (PPARs) via host and microbial derived processes
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Roles for Bile Transporters in the Pathogenesis and Treatment of Liver and Intestinal Diseases
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CD8 T cell Activation In Cancer Is Comprised Of Two Distinct Phases
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MBNL2 dependent dysregulation of GABAARs: Implications for CNS symptoms in Myotonic Dystrophy Type 1
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The Impact of Genetic Variation on RGS and G protein Signaling in Physiology and Disease
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Factors impacting the generation and maintenance of CD8+ tissue-resident memory T cells following respiratory immunization
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MEK inhibition mediates immunomodulatory factors and cell populations in advanced biliary tract cancer
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Ribosome Rescue, Remedies, and Resistance: Structural insights into bacterial translation regulation
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Oxytocin in Translation: Manipulating the Social Brain with Pharmacology and Contextual Stimuli
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Understanding how cocaine propels inflexible action strategies
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Understanding and Optimizing Gamma-Delta T cells as a Platform for Cellular Immunotherapies
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