Design, Synthesis, and Biological Evaluation of Subunit Selective N-Methyl-D-Aspartate Receptor Modulators

Expanding the Scope of Donor/Acceptor Carbenes and the Synthesis of Novel Therapeutic Agents for Cocaine Abuse

Part I: Synthesis of Cyclobutyl Nucleoside Analogs That Mimic AZT for Inhibition of the K65R HIV-1 Reverse Transcriptase Mutant Part II: Synthesis and Evaluation of Truncated Triptolide Analogs to Suppress Chronic Inflammation

Development of a Copper Catalyzed Aminoacetoxylation Reaction of Olefins, Development of an Intermolecular and Diastereoselective Iminium Cascade Reaction and Studies Towards the Synthesis of a Malagasy Alkaloid

Chapter 1: The development of a model system for the B-ring of brevenal and methods for the formation of seven-membered rings. Chapter 2: Iterative alkyne-epoxide cross-couplings toward the total synthesis of PM toxin A. Chapter 3: The development of synthons for 1,3-dimethylallylation of aldehydes.

Synthesis of 2'-Fluoro-2',3'-Dideoxynucleosides as Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase; Synthesis of Cyclobutyl Phosphonate and Phosphoramidate Prodrugs for Inhibition of HIV Reverse Transcriptase

Investigation of C-H Bond Oxidation Reactions: I. Asymmetric Amination of C-H Bonds Using Ruthenium(II) Catalysts II. Investigation of Structural Determinants of Monoamine Oxidase B

Use of Receptor-Based Drug Design and Applications in the Study of finding antagonists for MD-2/TLR4, GLP and CXCR4

Screening, hit expansion and mechanistic studies for natural product analogs derived from traditional herbal medicine: curcumin and triptolide.

Development of Monocarbonyl Curcumin Analogues Towards Treating Tuberculosis and Cancer

SYNTHESIS OF CYCLOPROPANES AND DIHYDROFURANS BY METAL CARBENOID REACTIONS

Validation of Receptor-Based Drug Design and Applications in the Study of IKKs, Truncated Taxane and LRH-1

Inhibition of the NF-κB signaling pathway by the curcumin analogs, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31) and 3,5-Bis(2-pyridinylmethylidene)-1-methyl-4-piperidone (UBS109): in-vitro and in-vivo studies.

Rhodium Alkenylcarbenes: Novel Reactivity and Precursors

Design, Synthesis, and Biological Evaluation of Subunit-Selective N-Methyl-D-Aspartate Receptor Antagonists

Structural Determinants of Activity, Mechanism and Structure Activity Relationships of Novel GluN2C/D Subunit Selective Antagonists of the N-methyl-D-Aspartate Receptor

ASYMMETRIC REACTIONS OF DONOR/ACCEPTOR RHODIUM CARBENOIDS: FROM FORMAL CYCLOADDITIONS TO C-H INSERTION

Organometallic Enantiomeric Scaffolds in the Synthesis of Alkaloids: I. Homo-SN2´-like Reaction/Annulative Demetallation and the Application in the Synthesis of (+)-Isofebrifugine II. Uncatalyzed Electrophilic C-C Bond Forming Reactions of Pyranyl and Pyridinyl Molybdenum Complexes

Design, Synthesis, and Biologic Evaluation of Tetrahydroisoquinoline-Based CXCR4 Modulators

Design, Synthesis, and Biological Evaluation of Subunit-Selective N-Methyl-D-Aspartate Receptor Modulators

Generating designer enzymes for therapeutic and industrial applications

Navigating the Roads to Drug Discovery: Part 1: Design, Synthesis, and Biological Evaluation of a Novel Class of Allosteric Modulators of N-Methyl-D-Aspartate Receptor Function Part 2: Discovery of Novel Tetrahydroisoquinoline (THIQ)-Based CXCR4 Antagonists and Conformational Analysis of Structurally Similar CXCR4 Antagonists

Design, Synthesis and Biological Evaluation of C4-C9 Bridged Epothilone Analogs

Computer-Assisted Drug Discovery Part I: Design, Development, Validation and Application of FRESH, a Novel In-Silico High-throughput Screening Program Part II: Monocarbonyl Curcumin Analogues: Heterocyclic Pleiotropic Kinase Inhibitors that Mediate Anticancer Properties Part III: Development of 2nd Generation NAMFIS Software Program by Java

Towards the Development of Non-Toxic Therapeutics in the Fight Against Cancer

Part I. Design of a novel class of reversible non-covalent small molecule inhibitors for human Granzyme B (hGrB) Part II. Curcumin and mimics as proteasome inhibitors Part III. Design of novel coactivator binding inhibitors (CBIs) for the estrogen receptor α : break the 1µM barrier

SYNTHESIS OF SMALL MOLECULE THERAPEUTICS UTILIZING RHODIUM CARBENOID CHEMISTRY

Multi-mechanism antiretroviral approach targeting macrophage derived viral sanctuaries

Use of Furans as Vehicles for Heterocyclic Synthesis: Anaza-Achmatowicz Approach to Piperidine Alkaloids, a Novel OxidativeRoute to Acyloxypyrrolinones, and IMDAF Studies Toward a Synthesisof Minfiensine and Morphine

Part I: Design, Synthesis and Biological Evaluation of C6-C8 Bridged Epothilone AnalogsPart II: Discovery of Small Molecule CXCR4 Antagonists

Engineering The Substrate Specificity Of Human Deoxycytidine Kinase

Synthesis and Characterization of Unusal Amphiphiles Part I. Nonsteroidal Facial Amphiphiles Part II. Diketopiperazine Derived Surfactants

Part 1: Stereoselective Synthesis of Quaternary Center BearingAzetines and β-Amino Acid Derivatives. Part 2: Natural andEnantiomeric Progesterone Analogues for the Treatment of TraumaticBrain Injury

Synthesis of Those Sectors of Saccharomicin A and B ContainingSaccharosamine and the Discovery of a Novel 4-H-1,3-OxazineSynthesis

Computational Studies of Ligand Protein Interactions Part I: TheT-Taxol Conformation Part II: Elucidating Interdependent BindingSites on Tubulin

Part I: Conformational Analysis of Bioactive Molecules inSolutionPart II: Structure-Based Design of Selective Inhibitors ofCyclin-Dependent Kinase 7

Synthesis of Altromycin and Kidamycin Aglycones from a Common Intermediate & Studies towards the Total Synthesis of Kidamycin

Metal Mediated Cross-Coupling Reactions for Carbon-Carbon andCarbon-Nitrogen Bonds Formation under Neutral pH Conditions

Part I: Synthesis of Cyclobutyl Nucleoside and NucleotideAnalogues as HIV-1 Reverse Transcriptase InhibitorsPart II: Improvement of Glycosylation Regioselectivity in PurineNucleoside Analogue SynthesisPart III: Enantioselective Synthesis ofβ-D-Dioxolane-T andβ-D-FDOC

Synthesis and Anti-Viral Activity of Novel 3,6-dioxa-[3.2.0]bicyclonucleoside Nucleotide Analogs

Part I: Structure and Function in the NMDA Ligand Binding DomainPart II: Comparison of Paclitaxel Analogs through MolecularDynamics Simulation; Solution Conformations of Cyclic Peptides

Analysis of the EF24-modulated signaling pathways for thedevelopment of novel cancer combination therapies

Part 1: Synthesis and Anti-HIV Activity of Novel CyclobutylNucleoside and Nucleotide Analogs, Part 2: Synthesis of FluorescentNucleoside Analogs, Part 3: Synthesis of Abacavir

Part I: Measles virus entry into cells and the inhibition offusion and replicationPart II: The nature of cyclostreptin's interaction withmicrotubules

Development of Fluorescence-based Molecular Tension Probes to Investigate Cellular Mechanical Forces

Discovery and Synthesis of Next Generation Chemokine Modulators with or without Concurrent HIV Reverse Transcriptase Inhibitory Activity

Part 1. Discovery of a Fluorinated Enigmol Analog with Enhanced Pharmacokinetic and Anti-Tumor Properties. Part 2. Preferential Activation of Metabotropic Glutamate Receptor 3 over Metabotropic Glutamate Receptor 2

The Design, Synthesis, and Biological Evaluation of Subunit-selective N-Methyl-D-Aspartate Receptor Potentiators