Structural Determinants of Activity, Mechanism and Structure Activity Relationships of Novel GluN2C/D Subunit Selective Antagonists of the N-methyl-D-Aspartate Receptor

Inhibition of the NF-κB signaling pathway by the curcumin analogs, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31) and 3,5-Bis(2-pyridinylmethylidene)-1-methyl-4-piperidone (UBS109): in-vitro and in-vivo studies.

Screening, hit expansion and mechanistic studies for natural product analogs derived from traditional herbal medicine: curcumin and triptolide.

Analysis of the EF24-modulated signaling pathways for thedevelopment of novel cancer combination therapies