Redox cycling and electrochemical features of copper-amyloid conjugates Open Access

Yue, Jipeng (Spring 2020)

Permanent URL: https://etd.library.emory.edu/concern/etds/zk51vj07b?locale=en%5D
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Abstract

Metalloproteins demonstrate the ability to perform novel reactions in biology, with even more potential functions stemming from protein engineering. Common laccases serve as examples of metalloproteins capable of performing redox catalysis on a variety of substrates. However, the lack of optimization, scalability and structural fidelity for common laccases limit their application within industrial settings. As a result, we looked towards an amyloid model in providing a scalable, green electrocatalyst. The resulting assembly, H-HHAQLVFFA-NH2, can be co-assembled with Cu(II) ions to generate a ribbon assembly at different timescales than unmetallized K16A. The resulting assembly exhibits a highly elevated reduction potential and can perform hydrogen peroxide evolution. 

Table of Contents

Introduction…………………………………………………………..………………………………………………..………………..8

Materials and Methods………………………………………………………………..………………………………………….11

Results……………………………………………………………………………………………………………………..……………..14

Discussions…………………………………..………………………………………………………………………………………….22

References Cited………………………………………………………………………………………………………………………25

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