Impact of Sleep Duration on Relative Telomere Length: A Systematic Review and Meta-Analysis Open Access
Bondy, Madison (Spring 2022)
Abstract
Introduction: As the global population continues to get older, it is imperative that we develop a deeper understanding of the many factors that contribute to healthy aging. Evidence shows that one of these factors is sleep duration, but reports on the nature and magnitude of the relationship between sleep and aging vary across the literature. The goal of this study is to elucidate this relationship by examining how sleep duration impacts telomere length (TL), a biological indicator of aging.
Methods: A systematic search was performed to identify peer-reviewed articles published between January 1, 2000 and June 1, 2021. These studies included measures of sleep duration and associated TL data. Studies with adequate data for inclusion in a meta-analysis were assessed for risk of selection bias, information bias, and confounding. Summary estimates were calculated for each study using random effects models and heterogeneity of results was assessed. Meta-regression analyses were then employed to examine sources of heterogeneity.
Results: The literature search initially identified 1,524 studies, of which 13 met inclusion criteria for systematic review. A qualitative analysis of the articles was conducted and eight of these studies (N=14,026, mean age=50.71, 44.06% male) were ultimately included in a meta-analysis. The summary effect of all included studies for average difference in mean TL between shorter (7 hours or less) and longer (more than 7 hours) sleep durations was -0.02 (95% CI: -0.03, 0.01). Meta-regression analyses on data sorted by average study population age (less than 50 vs. 50 years or older) produced a significant effect estimate of -0.04 (95% CI: -0.07, -0.03). The effect estimate was also significant within the younger subpopulation (less than 50 years), with an average difference in mean TL between sleep categories of -0.05 (-0.07, -0.03).
Conclusions: Evidence suggests that sleep duration significantly impacts telomere length, particularly among younger populations. Future research should examine this relationship using longitudinal data, and findings would be most reliable if objective measures of sleep duration are employed.
Table of Contents
Introduction........................1
Methods..............................4
Results................................8
Discussion...........................16
Conclusions.........................18
References...........................19
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