Birth Cohort effects of other cause mortality on ovarian cancer risk among Black and White women Open Access

Abstract

In the United States, Black women have a lower incidence of ovarian cancer compared to White women. Additionally, Black people are known to have higher all-cause mortality than their White counterparts. We sought to understand to what extent this difference in competing risks, other-cause mortality, may contribute to the disparity in ovarian cancer incidence between Black and White women. We built a state-transition Markov model in which we simulated counterfactual situations by varying other-cause mortality rates between Black and White women at risk of developing ovarian cancer. Applying this model, we observed the effects of altering other-cause mortality between Black and White women over a number of decades. Results indicate the racial disparity in ovarian cancer incidence between Black and White has decreased over the past decades. The incidence difference observed after varying other-cause mortality was 0.21% to 10.95% for Black women and -8.95% to -0.17% for White women. The gap between ovarian cancer incidence among Black and White women is larger in the older age groups than in younger age groups. To improve our assessment, we will need complete data from all ages for the studied time. The small sample size in older SEER data may also affect the precision of our results.

Table of Contents

Abstract

Background

Method

Result

Discussion

Conclusion

References

About this Master's Thesis

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School	Rollins School of Public Health
Department	Epidemiology
Subfield / Discipline	Epidemiology - MPH & MSPH
Degree	M.P.H.
Submission	Master's Thesis
Language	English
Research Field	Health Sciences, Public Health Women's Studies Health Sciences, Epidemiology
Keyword	Ovarian cancer
Committee Chair / Thesis Advisor	Schildkraut, Joellen, Emory University
Committee Members	Mandle, Hannah, Emory University

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