Atherosclerosis, Carotid Intima-Media Thickness, and DNA Methylation Open Access
Wong, Michael Gregory (2016)
Abstract
The rise of chronic disease has made the study of cardiovascular disease and atherosclerosis increasingly important. Cardiovascular disease is incredibly prevalent in the United States (over 1 in 3 adults) and is the single largest contributor to mortality nationally and globally. While traditional cardiovascular disease risk factors, such as smoking and high blood pressure, have been identified and studied for decades, advances in technology have helped identify risk factors such as carotid intima-media thickness (CIMT), measurable through ultrasonography, and DNA methylation, quantifiable through next generation sequencing (NGS). Using CIMT as a measure of the development of atherosclerosis, 13 CpG sites were identified to have an association between DNA methylation and the IMT variables.
Table of Contents
Background (page 1)
Methods (page 6)
Results (page 10)
Discussion (page 12)
Strengths and Weaknesses (page 14)
Future Directions (page 15)
References (page 16)
Tables and Figures (page 26)
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