Use of Anti-Inflammatory, Infliximab, may be an Alternative to Antidepressants for Treatment of Major Depressive Disorder Symptoms Restricted; Files Only

Yun, William (Spring 2022)

Permanent URL: https://etd.library.emory.edu/concern/etds/wm117q29w?locale=en
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Abstract

Importance: Psychomotor dysfunction is one of the nine diagnostic symptoms of major depressive disorder. Inflammation has demonstrated to potentially be related to Major Depressive Disorder and its symptoms. An anti-inflammatory could treat this inflammation and has the potential to treat other inflammatory-related depressive symptoms.

Objective: To determine the relationship between inflammatory cytokines and psychomotor speed, a diagnostic symptom of major depressive disorder, and to evaluate if Infliximab can treat the inflammation and consequently, the psychomotor speed.

Design/Setting: Clinical study.

Participants: 85 participants (ages 20-65) were recruited, 56 of those finished the entire study and they were considered depressed participants.

Main Outcome and Measures: Inflammatory cytokine marker concentrations and well-validated psychomotor speed tasks at screening and follow-up visits

Results: Infliximab did not significantly improve the psychomotor performance of depressive participants, but it did elicit significant improvements in inflammatory cytokine concentration.

Conclusion and Relevance: Anti-inflammatories such as Infliximab may be a potential anti-depressant treatment through inflammation, a potential correlate with depressive symptoms.

Table of Contents

Introduction…………………………………………………………………………………...…...6

Methods……………………………………………………………………………………………9

Results……………………………………………………………………………………………12

Discussion………………………………………………………………………………………..14

Tables and Figures……………………………………………………………………………….18

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References………………………………………………………………………………………..27

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