Systematic Review and Meta-Analysis of Very Low Carb Diets vs. Other Recommended Diets for Type-2 Diabetes Management Open Access

Albedint, Ahmad (Spring 2019)

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This study aims to examine the effect of very low carb diets compared to other recommended

diets in the Glycated hemoglobin (HbA1c) outcome in patients with Type 2 diabetes by

conducting a systematic review and meta-analysis of available RCTs.


We searched PubMed, Web of Science and the Cochrane Central Register of Controlled Trials.

Only randomized controlled trials (RCTs) were included, which compared very low carb diets

with other kinds of diets in diabetes type-2 patients. Meta-analysis using the fixed-effects model

were conducted for the HbA1c outcome.


A total of 11 studies involving 752 patients (368 in the low carb intervention group) were

included in this analysis. Quantitative meta-analysis shows significant decrease in the HbA1c of

type 2 patients after following very low carb for three and six months ((ES: 0.42; 95% CI: 0.19,

−0.65 ; P = 0.00) (ES: 0.45; 95% CI: 0.27,−0.63 ; P = 0.00), respectively).


Very low carb diet is superior to other recommended kinds of diets in controlling HbA1c for

patients with type 2 Diabetes mullites.

Table of Contents

Table of contents

Introduction   1

Methodology  3

A. Search strategy and Study selection         3

B. Data extraction and Quality assessment 4

C. Statistical Quantitative analysis   4

Results           5

A. Study selection      5

B. Study characteristics         6

C. Quality assessment           7

D. Quantitative analysis results        7

F. Publication Bias assessment         11

Discussion      12

Implications   13

References     14

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