Hearing loss modulates spatial tuning in mouse auditory cortex Open Access

Abstract

Hearing loss affects daily living for many people, particularly through its deleterious effects on spatial hearing. While some can recover spatial hearing ability, the underlying mechanism is not understood. Building on a mouse behavior task created by the Rodgers lab, I investigated the role of auditory cortex in spatial hearing and the effects of hearing loss on this region. My lesion experiments showed that auditory cortex was necessary for the task, but chemogenetic suppression did not affect the region. With tetrode recording, I recorded spatial tuning of auditory cortex neurons in freely moving mice. After hearing loss, auditory responses decreased, but some spatial tuning was retained. This work forms a foundation for further study of post-hearing loss recovery and the underlying drivers of spatial hearing in the brain.

Table of Contents

Introduction 1

Methods 5

Results 19

Discussion 36

About this Master's Thesis

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• Permission granted by the author to include this thesis or dissertation in this repository. All rights reserved by the author. Please contact the author for information regarding the reproduction and use of this thesis or dissertation.

School	Laney Graduate School
Department	Biological and Biomedical Sciences
Subfield / Discipline	Neuroscience
Degree	M.S.
Submission	Master's Thesis
Language	English
Research Field	Biology, Neuroscience
Keyword	Mouse Auditory system
Committee Chair / Thesis Advisor	Christopher Rodgers, Emory University
Committee Members	Malavika Murugan, Emory University Alan Emanuel, Emory University

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