Creation of a Functional Dynamic Chemical Network Open Access

Abstract

Life is a coherent system of myriad chemical networks we refer to as metabolisms. Metabolisms can be understood as systems that channel energy to generate molecular information, including sequence-specific polymers. The de novo synthesis of dynamic chemical networks (DCNs) which capture metabolic function promises to reveal new insights into the fundamental molecular principles of biological function. In this work, new designs for DCNs with expanded function and efforts in their synthesis are described. In particular, the synthesis and generation of peptide aldehydes via solid-phase peptide synthesis is detailed.

 

Table of Contents

1.    Introduction.                                                                                                           … 1

2.    Results.                                                                                                                     … 7

3.    Discussion.                                                                                                               … 11

4.    Future aims.                                                                                                             … 13

5.    Methods.                                                                                                                   … 14

6.    Outlines, figures & schemes.                                                                                … 16

7.    References.                                                                                                                … 26

About this Honors Thesis

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School	Emory College
Department	Biology
Degree	B.S.
Submission	Honors Thesis
Language	English
Research Field	Chemistry, General Chemistry, Biochemistry Biology, General
Keyword	Systems chemistry Alternative biochemistry Peptide chemistry Biochemistry Alternative backbone Synthetic biology Metabolism
Committee Chair / Thesis Advisor	David G. Lynn, Emory University
Committee Members	W. Michael Caudle, Emory University Gregg M. Orloff, Emory University

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