The Association between HIF-1a Activity and Time to Breast Cancer Recurrence in the Danish Breast Cancer Cooperative Group Open Access

Abstract

Background. HIF-1α has shown to be a biomarker in initial breast cancer biopsies to be associated with the incidence of recurrence after initial treatment. Multiple biochemical pathways have been hypothesized to give credence to these observed clinical outcomes. The focus of the study was the timing of the recurrence amongst patients who were registered to have had a recurrence and had available recurrent breast tissue sections to associate with HIF-1α’s activity.

Methods. Data utilized were from the Danish Breast Cancer Group (DBCG), a subample of a cohort that included 193 recurrent ER/TAM+ subjects and 116 ER/TAM- subjects, which were stratified for all ensuing analysis. Their tissue sections were stained and quantified utilizing immunohistochemical methods for HIF-1α activity and then considered as the main form of exposure in a multivariate logistic regression.

Results. Within the ER/TAM+ group it was observed that those with HIF-1ɑ nuclear activity would have a recurrence within 3 to 10 years 0.87 as many as times those without HIF-1ɑ nuclear activity rather than within 1 to 3 years after initial treatment, 95% confidence interval (0.45, 1.70). Similarly, the ER/TAM- arm of the study observed that those with HIF-1ɑ nuclear activity would have a recurrence within 3 to 10 years 0.60 as many times as those without HIF-1ɑ nuclear activity rather than within 1 to 3 years after initial treatment, 95% confidence interval (0.17, 2.04).

Conclusion. The observations shown herein demonstrate that among those who will have a recurrence of breast cancer, HIF-1α activity is more likely to be associated with an early recurrence of breast cancer rather than a later recurrence of breast cancer.

Table of Contents

Chapter 1: Page 9

Chapter 2: Page 12

Chapter 3: Page 19

About this Master's Thesis

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School	Rollins School of Public Health
Department	Epidemiology
Subfield / Discipline	Epidemiology - MPH & MSPH
Degree	M.P.H.
Submission	Master's Thesis
Language	English
Research Field	Health Sciences, Public Health Health Sciences, Oncology Health Sciences, Epidemiology
Keyword	Epidemiology Oncology Neoplasm HIF Public Health Breast Cancer
Committee Chair / Thesis Advisor	Timothy L. Lash, Emory University

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