The Structure of the Prodrome of Psychosis Open Access

Abstract

Psychotic disorder is a group of serious illness that affects the mind. The symptoms are severe and it affects over 5% of the population. Among illness that affect people aged in 15 to 44, schizophrenia is the 8^th leading cause of the disability worldwide. The first aim of this analysis is to conduct a latent class analysis on the clinical characteristics of adolescents at high risk of psychosis using the software Latent Gold. The second aim is to model the time to onset of psychosis in high-risk youth based on latent classes of comprehensive clinical information and socio-demographic variables. In this analysis, we used the Latent Class Analysis (LCA) approach to analyze variables collected as the North American Prodrome Longitudinal Study (NAPLS). The results showed that the four-class model was preferred according to the model selection criteria, such as AIC, BIC, and ICL-BIC. Based on these four subgroups, a proportional hazards model was used to characterize the relationship. In comparing the proportional hazards regression models with and without covariate measurement error, we found that the standard errors of the coefficients in the model with measurement error are smaller than the ones without measurement error.

Table of Contents

Contents
1. Introduction 1
2. Method 6
2.1 Coding Psychosis 6
2.2 Latent Class Analysis 7
2.2.1 Basic components of a Latent Class Cluster model 7
2.2.2 Probability Structure 8
2.2.3 Conditional distributions 9
2.2.4 Latent variable 10
2.2.5 Local independence 11
2.3 Proportional hazards model 12
2.4 Measurement with error 14
3. Results 17
4. Discussion 21
4.1 Discussion of results 21
4.2 Future work 21
5. Reference 24
6. Appendices 28
Appendix 1 28
Appendix 2 29

About this Master's Thesis

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School	Rollins School of Public Health
Department	Biostatistics and Bioinformatics
Subfield / Discipline	Biostatistics - MPH & MSPH
Degree	MSPH
Submission	Master's Thesis
Language	English
Research Field	Biology, Biostatistics Health Sciences, Public Health
Keyword	Latent Class Analysis Psychosis
Committee Chair / Thesis Advisor	Hanfelt, John, Emory University
Committee Members	Huang, Eugene, Emory University
Partnering Agencies	Does not apply (no collaborating organization)

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