PROSTATE CANCER SURVIVAL OF MEN IDENTIFIED AS 'BLACK' BY PLACE OF BIRTH IN THE UNITED STATES: SEER ANALYSIS 1988-2007 Open Access
Chung, Koo-Whang (2011)
Published
Abstract
Background: Prostate cancer is one of the most common
malignancies in men but
disproportionately affects black men compared to their white
counterparts, but these
disparities are also present across different subpopulations of
African ancestry. The
disparities associated with prostate cancer are well documented
between US whites
and blacks however, no population-based studies have been conducted
comparing
prostate cancer survival in US blacks by place of birth.
Methods: Data from the US Surveillance Epidemiology and End
Results (SEER)
program were used to compare the clinical and demographic
characteristics of
prostate cancer in 23,152 US born, 834 Caribbean born and 379
African born men
diagnosed between 1988 and 2007. Kaplan-Meier curves and
multivariate Cox
proportional hazard models were used to assess the effect of place
of birth on
prostate cancer survival.
Results: The unadjusted Kaplan-Meier Curves showed that
there is a statistically
significant increase in survival among Caribbean and African born
cases compared
to their US born counterparts (log-rank = 75,64, P-value =
<0.0001). After
controlling for confounders there was a statistically significant
increase in survival
for cases born in the Caribbean (HR = 0.68, 95% CI = 0.55, 0.84)
and in Africa (HR
= 0.46, 95% CI = 0.28, 0.75) compared to cases born on the US
(reference group).
Conclusions: This is the first population-based study that
looks at within-race disparities
of prostate cancer in the US including cases born in Africa. Our
analyses
demonstrated that survival among African-Americans is lower than
that of blacks
born in the Caribbean and Africa and this variation could represent
an underlying
difference in genetic, cultural, environmental, and dietary
factors.
Table of Contents
Table of Contents
Introduction........................................................................................................................
1
Methods.............................................................................................................................
3
Results...............................................................................................................................
5
Discussion...........................................................................................................................
7
References..........................................................................................................................
10
Tables and Figures
...............................................................................................................
12
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