Object Recognition Memory and Gamma Synchrony in the Rat Hippocampus Open Access
Trimper, John (2012)
Published
Abstract
Abstract
Object Recognition Memory and Gamma Synchrony in the Rat
Hippocampus
Neuronal oscillations are believed to play a critical role in
memory processing.
These rhythmic fluctuations in voltage facilitate the dynamic
routing of information to
and from various brain regions by transiently linking distinct
groups of cells. A recent
proposal is that intra-hippocampal oscillatory coherence in the
slow (30 - 55 Hz) and fast
(65 - 90 Hz) gamma bands reflect the processes of retrieval and
encoding, respectively
(Colgin & Moser, 2009). We sought to test this idea by
recording local field potentials
simultaneously from hippocampal subregions CA1 and CA3 in rats (
n= 5) as they
performed variants of a novel object recognition memory task.
Analyses failed to confirm
the hypothesized relationship between slow gamma coherence and
memory retrieval,
indicating instead that slow gamma coherence relates to the
processing of spatial and
relational memories. As predicted, oscillatory synchrony in the
fast gamma range was
related to memory encoding. However, our results suggest that this
relationship was
restricted to the encoding of nonspatial information. The current
study advances our
understanding of the functional relationship between hippocampal
gamma coherence and
memory, demonstrating a connection between oscillatory synchrony
and memory
content.
Keywords: hippocampus; memory; gamma; coherence; object
recognition
Table of Contents
Table of Contents
Introduction
.....................................................................................................................................
1
Method
............................................................................................................................................
3
Subjects
...............................................................................................................................
3
Apparatus
............................................................................................................................
3
Procedure
............................................................................................................................
5
Data Analysis
.......................................................................................................................
6
Results
.............................................................................................................................................
8
Histology
.............................................................................................................................
8
Behavior
..............................................................................................................................
8
Local field potentials
.........................................................................................................
10
Discussion
......................................................................................................................................
14
Slow gamma coherence relates to spatial and relational information
content ............... 15
Fast gamma coherence relates to the encoding of nonspatial
information .................... 17
Conclusions
.......................................................................................................................
19
References
...........................................................................................................................
21
Figures & Tables
...................................................................................................................
26
Figure 1: Task schematic
...................................................................................................
26
Figure 2: Average changes in exploration times
...............................................................
27
Figure 3: Coherence on laps 1 and 2 for each object type
............................................... 28
Figure 4: Moving window coherogram for coherence changes
across laps ..................... 29
Table 1: Significant coherence changes for same object/same
location ......................... 30
Table 2: Significant coherence changes for same
object/different location .................... 31
Table 3: Significant coherence changes for different
object/same location .................... 32
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