Associations between Gastrointestinal Transit Time and Body Composition Metrics Restricted; Files Only
Parquette, Ariana (Spring 2025)
Abstract
Abstract
Associations between Gastrointestinal Transit Time and Body Composition Metrics
By Ariana Parquette
Background: Obesity is bidirectionally associated with gastrointestinal motility disorders across the GI tract. Measures of central obesity are stronger predictors of obesity-related outcomes, such as colorectal cancer and metabolic syndrome, as compared to traditional metrics of obesity.
Objective: To evaluate the relationship between gastrointestinal (GI) transit time and central adiposity.
Methods: Thirty adults (50% women, 50% African American) were included in this cross-sectional study. Android-gynoid ratio and visceral adipose tissue mass were measured by dual energy x-ray absorptiometry, and waist circumference was measured by a trained dietitian. Gastric emptying time, colonic transit time, and whole gut transit time were simultaneously evaluated by a Smart Pill wireless motility capsule, which was ingested together with a standardized meal and 8oz bottle of water. Linear regression models were applied to assess associations between gastrointestinal transit time and body composition.
Results: Overall median age was 60.0 years (IQR: 55.0-63.0) and median BMI was 31.9 kg/m2 (IQR: 28.8-36.5). Median waist circumference among men and women were 112.5 cm (IQR: 106.5-123.2). and 103.7 cm (IQR: 95.3-113.4) respectively. For every standard deviation increase (SD = 64 minutes) in gastric emptying time, waist circumference was 3.03 centimeters [SD: -2.4, 8.4] (P-value =0.26) greater and visceral adipose tissue mass was 0.2 kg [SD: -0.15, 0.51] (P-value = 0.26). For each standard-deviation longer colonic and whole gut transit time, visceral adipose tissue mass was 0.13 kg [SD: -0.41, 0.28] (P-value = 0.71) and 0.16 kg [-0.40, 0.28] (P-value = 0.72), respectively. Gastrointestinal transit time showed modest, inconsistent associations with android-gynoid ratio.
Conclusions: Slower gastric emptying was associated with an increased waist circumference and visceral adipose tissue mass. Slower colonic and whole gut transit time were associated with lower visceral adipose tissue mass.
Table of Contents
Table of Contents
CHAPTER I 1
Literature Review/Background 1
CHAPTER II 10
Introduction 10
Methods 11
Results 15
Discussion 17
TABLES AND FIGURES 25
Table 1 25
Table 2 26
Table 3 27
Table 4 28
REFERENCES
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File download under embargo until 15 May 2027 | 2025-05-01 14:15:05 -0400 | File download under embargo until 15 May 2027 |
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