Massive Transfusion as a Predictor of Survival in Pediatric Patients Receiving Extracorporeal Life Support Open Access
Winkler, Anne Marie (2013)
Abstract
Extracorporeal life support (ECLS) is a technique that has been shown to be effective in supporting patients of all ages with life-threatening cardio-respiratory failure of varying etiologies and has become the standard therapy for neonatal, pediatric and adult patients with acute cardiac or respiratory failure that is unresponsive to traditional management. As a result of added extracorporeal volume, acquired hemostatic changes, and occurrence of hematologic complications, transfusion requirements associated with ECLS are very high and patients are commonly massively transfused; however, associations between massive transfusion, complications, and all-cause mortality have not been formally investigated in ECLS patients. One prior study demonstrated a weak association between each packed red blood cell (RBC) transfusion volume of 10 ml/kg/day and in-hospital mortality (OR 1.024, CI 1.004-1.046, p=0.018) in ECLS patients(15). As a result, a cohort study of all ECLS patients less than 18 years of age was conducted at a single institution from 1/1/2009 - 12/31/2011 to examine the association between massive transfusion, defined as RBC transfusion of greater than one blood volume plus circuit volume based upon on patient weight, complications, and all-cause mortality. In this cohort, massive transfusion which occurred in 32.7% of the entire cohort and 36.3% of neonatal subjects was associated with increased all-cause mortality, and this effect was stronger for neonates (OR 6.45, CI 1.81-22.9, p=0.004). Kaplan-Meier estimates for the probability of death did significantly differ between subjects who were massively transfused versus those who were not (Log rank <0.0001) and the effect of massive transfusion was time-dependent. Subjects who were massively transfused with an ECLS duration greater than 4 hours had an increased hazard of death (HR 3.38, CI1.59-7.20, p=0.002) when controlling for ECLS mode. As a result, massive transfusion is independently associated with an increased risk for all-cause mortality, similar to investigations linking RBC transfusion to increased morbidity and mortality in non-ECLS critically ill patients.
Table of Contents
INTRODUCTION…………………………………………………………. 1
BACKGROUND…………………………………………………………… 2
METHODS…………………………………………………………………
6
RESULTS………………………………………………………………….. 10
DISCUSSION……………………………………………………………… 13
REFERENCES…………………………………………………………….. 16
TABLES AND FIGURES………………………………………………… 18
About this Master's Thesis
| School | |
|---|---|
| Department | |
| Degree | |
| Submission | |
| Language |
|
| Research Field | |
| Keyword | |
| Committee Chair / Thesis Advisor | |
| Committee Members |
Primary PDF
| Thumbnail | Title | Date Uploaded | Actions |
|---|---|---|---|
|
|
Massive Transfusion as a Predictor of Survival in Pediatric Patients Receiving Extracorporeal Life Support () | 2018-08-28 13:49:30 -0400 |
|
Supplemental Files
| Thumbnail | Title | Date Uploaded | Actions |
|---|