Association of an Evolutionary-concordance Lifestyle Pattern Score, Alone and Jointly with an Evolutionary-concordance Diet Pattern Score, with Biomarkers of Systemic Oxidative Stress and Inflammation Restricted; Files Only

Padathara Mathew, Reji (Spring 2022)

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Consistent with the evolutionary-discordance hypothesis, lifestyle and dietary patterns considered more evolutionary-concordant were associated with lower risk for colorectal adenoma and cancer, and all-cause, all-cancer, and all-cardiovascular disease mortality. Important mechanisms underlying these associations may involve the collective effects of multiple lifestyle and dietary exposures on inflammation and oxidative stress. Indeed, a more evolutionary-concordant, 14-component, diet pattern score (EC diet score) was associated with lower circulating concentrations of biomarkers of systemic inflammation (high sensitivity C-reactive protein [hsCRP]) and oxidative stress (F2-isoprostanes [FiP]). To investigate whether a more evolutionary-concordant lifestyle pattern score (EC lifestyle score; comprising smoking status, body mass index, and physical activity), alone and combined (total EC score) with the previously-reported more evolutionary-concordant 14-component EC diet score, is associated with circulating hsCRP and FiP concentrations, we analyzed data from two pooled cross-sectional studies among 30–74-year-old men and women (n=677). We categorized the EC scores as low, moderate and high, and from general linear regression models, mean circulating hsCRP and FiP concentrations among those in the highest (most evolutionary-concordant) relative to the lowest EC lifestyle score, were 45.5% (P<0.01) and 19.2% (P<0.01) lower, respectively; for the total EC score they were 51.1% (P<0.01) and 19.8% (P<0.01) lower, respectively. The findings were similar by sex and regular use of non-steroidal anti-inflammatory drugs and multivitamin/mineral supplements. Our results suggest that more evolutionary-concordant lifestyle patterns, alone and combined with more evolutionary-concordant diet patterns, may be associated with lower systemic inflammation and oxidative stress. 

Table of Contents

Chapter 1: Background

Chapter 2: Manuscript for Submission for Publication in a Peer-Reviewed Journal

Chapter 3: Public Health Implications and Future Research Work

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