The Influence of Hypercholesterolemia on Cognitive Impairment in Age 65-74: A NACC Cross-Sectional Study Open Access

Yue Zhang (Summer 2024)

Permanent URL: https://etd.library.emory.edu/concern/etds/bc386k797?locale=en
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Abstract

Cognitive impairment is a progressive neurodegenerative disorder characterized by significant cognitive decline. Some research suggests that cholesterol plays a role in cognitive impairment pathogenesis. This study investigates the relationship between hypercholesterolemia and cognitive impairment among individuals aged 65 to 74. We used logistic regression to evaluate the impact of hypercholesterolemia and cognitive impairment, adjusted for some confounders, including race, sex, education, diabetes, hypertension, smoking, and BMI, and stratified by age categories. The association is robust after adjusting for confounders, suggesting that hypercholesterolemia is a significant risk factor for cognitive impairment. These findings support cholesterol management as a potential strategy to modify cognitive impairment risk.

Table of Contents

Table of Contents

1.   Abstract

2.   Acknowledgments

3.   Introduction

4.   Literature review

4.1.    Cognitive Impairment

4.1.1.    Montreal Cognitive Assessment (MoCA) in the Detection of Cognitive Impairments

4.2     Hypercholesterolemia

4.2.1.    Hypercholesterolemia

4.2.2.    Cholesterol, hypercholesterolemia, and cognitive impairments

5.   Aims

6.     Materials and Methods

6.1  Data Collection

6.2.    Data analysis

7.   Results

8.   Discussion

9.   Conclusion

10. References

11. Supplement

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