Quality of Life Factors Influencing Post-Diagnosis Change in BMI in a Cohort of Breast Cancer Patients Open Access

Taylor, Melissa Anne (Spring 2018)

Permanent URL: https://etd.library.emory.edu/concern/etds/b5644r577?locale=en


Introduction and Objectives: Weight gain during breast cancer treatment is well documented in the literature and has been associated with chemotherapy treatment, hormone therapy, age, stage at diagnosis, and menopause status.  The effects of quality of life factors on post-diagnosis weight gain have not been well studied. We examined the effect of measures of quality of life on post-diagnostic weight gain in breast cancer patients treated with radiation and surgery.

Methods: We enrolled 140 female breast cancer patients receiving radiation treatment at the Emory University Winship Cancer Institute in Atlanta, GA from March 2010-November 2011. Body mass index (BMI) was recorded at five different time points during the study, from baseline to one year post diagnosis and percent BMI change was measured from baseline to the end of follow-up. Quality of life was measured by the validated 36-Short Form Survey (SF-36) at the same time points as BMI to assess trends and overall change. The association between quality of life measures and BMI change was evaluated in multivariate linear regression models after adjustment for confounders.

Results: The individual SF-36 component scores were not statistically significant determinants of baseline BMI. A modest inverse association between the physical functioning component score and baseline BMI and was borderline significant (P=0.06). A one unit higher physical functioning score was associated with a lower BMI (-0.05 95% CI= -0.11-0.003). None of the other component scores were significantly associated with baseline BMI and no SF-36 scores were associated with BMI change.

Conclusions: In this study population there was little or no association between quality of life and either baseline BMI or breast cancer treatment associated change in BMI. 

Table of Contents

Background 8-11 

Materials and Methods 12-14 

Results 15-17

Discussion 18-20

Tables and Figures 21-26 

References 27-28


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