Serum Acrylamide Level and Self-Reported Health Status in U.S. Women of Reproductive Age, NHANES 2003-2004 Open Access

Diaz, Diana (2015)

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BACKGROUND: Acrylamide is a chemical compound formed in foods processed at high temperatures (frying and baking). Dietary exposure to acrylamide has been associated with adverse birth outcome in humans; however, evidence has been inconclusive and requires further investigation.

METHODS: Using data from the 2003-2004 National Health and Nutrition Examination Survey (NHANES), we conducted a cross-sectional study to examine the association between serum acrylamide levels and self-reported health among women of reproductive age. Using multivariable logistic regression, we estimated adjusted odds ratios (aORs) and 95% confidence intervals (CIs). We also examined interaction between acrylamide and race and ethnicity, age, serum cotinine level, and frequency of restaurant foods consumption per week.

RESULTS: The mean serum acrylamide level among women who reported poor health status was 93.05 pmol/G Hb compared to 78.81pmol/G Hb in those with good health status (P value = 0.01). Multivariable logistic regression showed a positive, but non-significant association between highest quartile of serum acrylamide exposure and poor self-reported health (aOR=1.82; 95% CI= 0.91, 3.70), controlling for age, race and ethnicity, education, citizenship status, family income, number of times health care was utilized in the previous years, and serum cotinine levels. There was significant effect modification due to the race (p=0.03) and serum cotinine (p=0.001) on the association between serum acrylamide levels and self-reported health among study participants.

CONCLUSIONS: High serum acrylamide level was associated with the self-reported health status among women of reproductive age in the NHANES, and the effect is further modified by race and ethnicity. Future studies should examine the association in a prospective study design.

Table of Contents

Publication Cover Sheet: 1

Abstract for Publication: 2

Expanded Introduction: 3

Introduction for Publication: 7

Methods: 11

Results: 15

Discussion: 18

Expanded Discussion: 22

Table 1: 28

Table 2: 29

Table 3: 30

Table 4: 31

References: 32

Appendix 1: 36

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