Maternal dietary inflammatory index score during pregnancy is not associated with the development of respiratory outcomes in early childhood Open Access

Abdelhadi, Jenna (Spring 2021)

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Background: The inflammatory potential of maternal diet during pregnancy may influence the development of childhood wheeze and asthma.

Objective: To examine the relationship between the inflammatory potential of maternal diet during pregnancy and likelihood of developing wheeze and asthma in early childhood.

Methods: The Conditions Affecting Neurocognitive Development in Early Childhood (CANDLE) study is a prospective cohort of 1503 mother-child dyads in Shelby County, Tennessee. Second trimester maternal dietary and supplement intakes, assessed using the 2005 Block food frequency questionnaire, were used to calculate dietary inflammatory potential using the energy-adjusted dietary inflammatory index (E-DII®). E-DII is an a priori dietary pattern that classifies diets on a continuum from maximally anti-inflammatory to pro-inflammatory. Current wheeze (age 3y N=167; age 4-6y N=183) and ever asthma (age 4y N=136) were assessed by parental report. Recurrent wheeze was calculated from affirmative responses to current wheeze at age 3y and 4-6y (N=82). Multivariable logistic regression was used to assess the relationships between quartiles of maternal E-DII and child wheeze and asthma outcomes.

Results: The prevalence of age 3y current wheeze, age 4-6y current wheeze, recurrent wheeze, and ever asthma was 20.0%, 20.9%, 8.8%, and 14.9%, respectively. The E-DII scores ranged from -6.3 to 4.9 with mean -1.6. There was no association between E-DII and wheeze and asthma outcomes in adjusted analyses. The aOR for E-DII quartile 4 (pro-inflammatory) vs. quartile 1 (anti-inflammatory) was: 1.1 (95% CI: 0.70, 2.06) for age 3y current wheeze; 0.93 (95% CI: 0.57, 1.53) for age 4-6y current wheeze; 1.38 (95% CI: 0.69, 2.8) for recurrent wheeze; and 1.39 (95% CI: 0.80, 2.43) for ever asthma.

Conclusions: The inflammatory potential of second trimester maternal dietary and supplement intake, as assessed by the E-DII, was not associated with wheeze and asthma development in early childhood.

Table of Contents

Introduction 1

Methods 3

Results 8

Discussion 10

References 16

Figures 23

Tables 24

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