Neural correlates of Recollection and Familiarity responses in episodic memory: A Seed-based d Mapping Meta-Analysis Open Access

Yang, He (Spring 2021)

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According to the dual process theory of episodic memory retrieval, successful memory retrieval for specific events can be obtained through two distinct processes known as recollection and familiarity (Tulving, 1985). The two processes are distinguishable at a neurological level based on neuropsychiatric and neuroimaging evidence, which suggested that different subregions of the frontal, parietal and medial temporal lobe were involved differentially for recollection and familiarity (Eichenbaum, Yonelinas, & Ranganath, 2007; Ranganath, 2010; Spaniol et al., 2009). However, huge variance resides in results from past neuroimaging studies, possibly due to the small sample size and methodological difference between them (Skinner & Fernandes, 2007; Spaniol et al., 2009). Here we provide a quantitative summarization of neural correlates for recollection and familiarity by employing the meta-analytic method seed-based d-mapping (SDM) to summarize findings across studies that reported contrasts including recollection > familiarity and familiarity > miss/correct rejection (Tulving & Craik, 2005). Consistent with our hypothesis, we found unique subregions that activate more for recollection including the parahippocampal cortex and default mode network regions. We also found significant activations of ventral network regions associated with familiarity responses. Sub-analyses based on different retrieval paradigms were also conducted in order to assess the influence of methodological difference upon the results. We found distinctive results between analyses based on the remember-know and source memory paradigms. Results also favored the use of remember-know paradigm over source memory to distinguish recollection from familiarity. The current findings illustrate the involvement of parahippocampal and default mode network regions associated with contextual details and self-referential content in recollection and the involvement of salience processing related ventral network regions in familiarity responses. In addition, our results provide guidance in task selection and design for relevant future research.

Table of Contents

Table of Contents

1.     Introduction. 1

1.1.. The dual-process model of episodic memory. 1

1.2.. fMRI study design for recollection and familiarity. 5

1.3 Previous Meta-analyses. 7

1.4 Seed-based d Mapping meta-analysis. 10

1.5 Current Study. 10

2.     Methods. 12

2.1.. Inclusion and exclusion criteria. 13

2.1.1  Neuroimaging method. 14

2.1.2  Participants. 14

2.1.3  Stimuli 15

2.1.4 Retrieval tasks. 15

2.1.5 Contrasts of interests. 16

2.1.6 Description of included studies. 17

2.2.. Seed-based d Mapping meta-analysis. 24

2.2.1 Supplemental analyses. 25

2.2.2 GLM analysis for remember-know studies vs. source memory studies. 25

3.     Results. 26

3.1.. Neural correlates for recollection. 26

3.2.. Neural correlates for familiarity. 32

3.3.. Supplementary analyses results. 36

3.4.. GLM analysis results. 52

4.     Discussion. 55

4.1.. Activations different for recollection and familiarity. 55

4.1.1 Differences in the MTL memory system.. 56

4.1.2 Recollection involves the default mode network. 57

4.1.3 Familiarity involves the ventral network. 58

4.1.4 Parietal dissociations between recollection and familiarity. 59

4.2.. Comparisons between different retrieval paradigms. 60

5.     Conclusion. 62

Reference. 64

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