Association of combined mineral intakes with risk of incident, sporadic colorectal adenoma Open Access

Raavi, Tapasya (Spring 2019)

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 There are few reported epidemiologic studies on associations of mineral intakes other than calcium, with colorectal neoplasms, and just one of those studies investigated multiple minerals in aggregate. In the latter study, a higher mineral score was statistically significantly inversely associated with incident colorectal cancer. We incorporated 8 minerals into a mineral intake score and investigated its association with incident, sporadic colorectal adenomas, using pooled data from three case-control studies (n = 779 cases, 2,026 controls) conducted in Minnesota, North Carolina, and South Carolina. Participants’ mineral intakes were expressed as nutrient densities and categorized according to their distributions among the controls. Total (dietary plus supplemental) calcium, magnesium, zinc, and potassium intake quintiles were assigned scores of 1 – 5, with higher ranks indicating higher, potentially anti-colorectal carcinogenic intakes, whereas iron, copper, phosphorus, and sodium intake quintiles were assigned scores in the reverse order to account for their possible pro-colorectal carcinogenic properties. The rankings were summed to create participants’ mineral scores, and the association of the score with incident, sporadic colorectal adenomas was estimated using multivariable unconditional logistic regression. The multivariable-adjusted odds ratios (OR) for the mineral score-adenoma association were close to null (e.g., the OR for those in the highest relative to the lowest score quintile was 1.05 (95% confidence interval 0.81, 1.37). Our findings suggest that higher calcium, magnesium, zinc, and potassium intakes, combined with lower iron, copper, phosphorus, and sodium intakes may not be associated with incident, sporadic colorectal adenoma risk. 

Table of Contents

Introduction, 1

Materials and Methods, 2

Results, 6

Discussion, 8

References, 13

Tables, 19

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