Association of Schistosoma haematobium and Plasmodium falciparum Infection in Nigerian Children Open Access
Kimbley, William (Spring 2021)
Both schistosomiasis and malaria are major public health concerns in sub-Saharan Africa. There are approximately 29 million Nigerians infected with schistosomiasis and an additional 101 million at risk for infection out of a total population of 201 million. In comparison, there are 100 million Nigerians infected with malaria with 195 million at risk of infection.
This study examined the association between these two parasitic infections in Nigerian children using a combination of univariate and multivariate regression analysis. Independent variables were selected using a Chi Squared Test of Independence. Chosen variables included age, gender, residence type, residence zone, wealth quintile, mosquito net ownership, and the variable of interest, schistosomiasis symptoms.
Data from the 2008 Nigeria DHS survey were analyzed to find variables affecting the prevalence of malaria infection. The analysis showed a significant protective effect of schistosomiasis infection on malaria infection (OR=0.85, 95% CI= 0.79 - 0.91, p<0.01). Gender was also found to have an effect on symptoms of schistosomiasis, with males having a higher prevalence than females (p<0.001).
Children showing symptoms of a schistosomiasis infection are 1.17 times less likely to have an active malaria infection than those who do not show signs of a schistosomiasis infection. The data may have under reported true schistosomiasis infection rates, as only symptoms were recorded and not verified parasite loads. This should be considered when evaluating both schistosomiasis and malaria interventions in sub-Saharan Africa.
Table of Contents
TABLE OF CONTENTS
Main Body 8
Study Area 12
data collection 12
Statistical Analysis 14
Independent Variables 14
Risk Factors for malaria 17
Multivariate Analysis 19
Table 1: Demographic Information 30
Table 2: Independent Variable encoding 31
Table 3: Univariate analysis results 32
Table 4: Multivariate Analysis Results 33
Summary, Public Health Implications, Future Directions 35
About this Master's Thesis
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|Association of Schistosoma haematobium and Plasmodium falciparum Infection in Nigerian Children ()||2021-05-03 21:29:31 -0400||