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Ancestral Sequence Reconstruction as a Lead Optimization Approach in Gene Therapy Drug Development
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Discovery of Novel Natural Products to Combat Multidrug Resistant Bacteria and Fungi
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Botanicals As A Source Of Novel Therapeutics For Infectious Diseases
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Elucidating the Lysosomal Function of Granulins
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Streamlined Approach to Identify Novel Immunomodulatory Agents to Mitigate Ischemic Stroke in a Primary Microglia Model
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Determining the impact of the RGS14-Gαi1-GDP complex on NHERF1 binding
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Development of a Targeted Identification Platform of Small Molecule Inhibitors for Rare and Orphan Diseases
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GluN2B-Selective NMDA Receptor Negative Allosteric Modulation as a Treatment for Chronic Pain and Opioid Tolerance
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Studies in Small Molecule Drug Discovery: Part I. Synthesis of Novel Nucleoside-Based Antivirals to Treat Hepatitis C; Part II. Validation and Implementation of a Machine Learning Algorithm to Create a Safer Kinase Inhibitor as a Potential First-in-Class Antiparkinsonian Agent
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Investigating the therapeutic role of EP2 antagonism in two-hit mouse model of Alzheimer’s disease
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Pharmacological analysis of liver-directed AAV-fVIII gene therapy and anti-fVIII inhibitor incidence in a preclinical model of hemophilia A
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Morse Fall Scale Score Impact on Administration of Benzodiazepines and Opioids
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The impact of rare human genetic variants and disease-linked mutations of RGS14 on the RGS14-Rap2A interactions and the regulation of JNK signaling
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Linezolid Use and Cytopenias in Patients Treated for Multidrug-resistant Tuberculosis
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Development of a novel antibiotic adjuvant strategy against hypervirulent Community-Associated Methicillin-Resistant Staphylococcus aureus
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Inhibiting VIP Receptor Signaling Promotes T Cell Mediated Immune Response in Murine Melanoma Models
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Nitric Oxide Mediated Degradation of CYP2A6 via the Ubiquitin-Proteasome Pathway in Human Hepatoma Cells
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Synthesis, Structure-Activity Relationship, and Biological Evaluation of Subunit-Selective NMDA Receptor Modulators
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Gut microbiome product delta-valerobetaine controls host metabolism
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Abnormal Recovery from Anesthesia: A Marker of Early Cognitive Dysfunction in Rodent Models of Disease
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Investigating the Role of the Pre-M1 Helix and Other Highly Conserved Regions in NMDA Receptor Function
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The Effects of Co-Prescribing Anti-Epileptic Drugs and Antidepressant Medications among African Americans with Epilepsy at Grady Hospital: A Case-Crossover Study
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Effect of 5-FU Bolus on Survival in Patients with Metastatic Colorectal Cancer Treated with Combination Chemotherapy
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Potential Cross-Talk between the Aryl Hydrocarbon Receptor (AHR)
and the Constitutive Androstane Receptor (CAR)
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Multi-mechanism antiretroviral approach targeting macrophage
derived viral sanctuaries
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On the Modulation of CFTR Channel Function by Sphingomyelinase and
VX-770
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Duration of Hepatitis C Treatment with Direct-acting Antivirals
Ledipasvir/Sofosbuvir Not Associated with HIV Co-Infection
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The Role of RGS14 in Learning, Memory, and Synaptic Plasticity
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Regulator of G Protein Signaling 14 (RGS14) at the Interface of
Conventional and Unconventional G Protein Signaling
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Neurochemical, neuroprotective, and behavioral effects of enhanced
vesicular storage of dopamine
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Optimization of Dual-tropic CXCR4/CCR5 HIV-1 Entry Inhibitors and a
Market Analysis
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Inhibition of multidrug-resistant bacteria by Civil War plant
medicines
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Regulation of Adhesion G Protein-Coupled Receptor ADGRG1 (GPR56) by
Receptor Activity-Modifying Proteins
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Therapeutic effect of Berberine on Huntington's Disease Transgenic Mouse Model
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Regulation of Myelin Proteins and Protection Against Demyelination
by GPR37 Signaling
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Characterizing the Downregulation of CYP2J2 by Nitric Oxide
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Multi-modal Signaling and Regulation of the Adhesion G
Protein-coupled Receptor ADGRG1 (GPR56)
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Mechanisms of insulin-like growth factor 1 receptor-mediated
trastuzumab resistance in human epidermal growth factor receptor
2-overexpressing breast cancer
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The Senescence-Accelerated Mouse (SAM): A Murine Model of
Age-Associated Diastolic Dysfunction
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Effect of M1 Muscarinic Receptor Activators on Locomotion in Rats
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Degree of plasma protein binding affects central nervous system
(CNS) free drug penetration for the HIV-1 protease inhibitors among
patients in an urban HIV clinic.
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Regulation of cocaine- and amphetamine-regulated transcript
expression by cyclic AMP response element binding protein
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Disruption of Monoamine Homeostasis in Models of Neurological and
Neuroendocrine Diseases
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Antiretroviral Therapy and Bone Loss in HIV-Infected Individuals
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Cortical mechanisms and developmental contributions to habit formation
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Microbiome Composition and Female Genital Tract Compartmental Antiretroviral Drug Exposure in HIV-Infected Women
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Coronin 1B Regulates Platelet-derived Growth Factor-induced
Migration and Reactive Oxygen Species Production
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The relationship between antiretroviral drug concentrations and persistent low-level viremia among HIV-infected women in the United States
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Novel Systems to Investigate Interactions between Functional RNAElements and Candidate Trans-factors
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Examination of Phasic and Sustained Fear Responses Using a Novel
Sustained Fear Conditioning Paradigm
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Sulfur Amino Acid and Acetaminophen Effects on Extracellular
Thiol/Disulfide Redox Potentials
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In Vivo Investigation of Escitalopram's Allosteric Site on the Serotonin Transporter
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Studies of the structure, regulation, and pharmacology of the cystic fibrosis transmembrane conductance regulator
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Targeting Cell Survival Signaling for Therapeutic Discovery
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REDOX-SENSITIVE REGULATION OF MRTF-A PHOSPHORYLATION VIA PALLADIN
IN VASCULAR SMOOTH MUSCLE CELL DIFFERENTIATION
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The Role of Arachidonate 5-Lipoxygenase in HIV-associated Pulmonary
Hypertension
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Microglial motility under pro-inflammatory conditions in situ:
Relevance to neurodegeneration
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Reduced vesicular storage of catecholamines in the pathogenesis of
Parkinson's Disease
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Activation and regulation of the brain-expressed adhesion G
protein-coupled receptors ADGRB1/BAI1 and ADGRB2/BAI2: Implications
for human disease
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The Use of 5-Aminolevulinic Acid and Spectroscopic MRI in the
Management of Patients with Glioblastoma
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Factors that modulate Ca2+-dependent regulation ofCav2.1 (P/Q-type) Ca2+ channels
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Protein-Protein Interactions Regulating ASK1 Function
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Characterization of a novel nucleoside analog for dengue virus infection
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Bioengineering Viral Transgenes for the Treatment of the Hemophilias
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Optimization of a Lentiviral Vector for use in an HSC Gene Therapy
Protocol for Hemophilia A
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Integrationof Heterotrimeric G Protein Signaling by the Regulator of G Protein Signaling 14 (RGS14): Independent Regulation of Gα Signaling by the RGS Domain and GPR Motif
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Investigating the Effects of Specific Acetylcholine Receptor
Activation on Hippocampal Function for the Treatment of Alzheimer's
Disease
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The Interplay Between Reverse Transcription and SAMHD1 Degradation: Mechanistic Differences Between Reverse Transcriptases from HIV-1, HIV-2 and SIV Lentiviruses Able or Unable to Degrade SAMHD1
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Development of Monocarbonyl Curcumin Analogues Towards Treating
Tuberculosis and Cancer
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Regulation of Endothelial Tetrahydrobiopterin in Normal and
Pathophysiological States
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Role of 3' untranslated regions in translation regulation of
GluR2 mRNAs
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Discovery, characterization, and lead optimization of 7-azaindolenon-nucleoside HIV-1 reverse transcriptase inhibitors
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Catecholamines and Arousal
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Screening, hit expansion and mechanistic studies for natural
product analogs derived from traditional herbal medicine: curcumin
and triptolide.
74 of 100
Discovery and Development of Selective M1 Agonists
that Protect Against Alzheimer's Pathology and Bias Hippocampal
Circuitry Dynamics in Rodents
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Poldip2: An investigation of structure and signaling pathways to
elucidate the function of a novel cell cycle regulator.
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The long-term effects of prenatal stress and/or antidepressant
exposure in rats
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Impaired vesicular storage of norepinephrine and serotonin in Parkinson's disease-related pathogenesis
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Structural and Functional Studies of the Orphan Nuclear Receptor
LRH-1
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PRAS40 and mTOR Signaling: A Paradigm for Crosstalk Among
Proliferation, Growth, and Stress Signaling
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Signaling, Regulation, and Synaptic Role of Adhesion G
protein-coupled Receptor Brain-specific Angiogenesis Inhibitor-1
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Time-dependent determination of inflammatory mediators in a 5xFADmouse model of Alzheimer's disease
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High dose oral amoxicillin attains pharmacokinetic efficacy
endpoints in young infants (0-59 days) with suspected sepsis - a
population pharmacokinetic pilot study
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The Effects of Early Life Stress on Decision Making Under Risk,
Response Inhibition, and Error Processing as Risk Factors for
Cocaine Addiction
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Part 1. Discovery of a Fluorinated Enigmol Analog with Enhanced Pharmacokinetic and Anti-Tumor Properties. Part 2. Preferential Activation of Metabotropic Glutamate Receptor 3 over Metabotropic Glutamate Receptor 2
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Comprehensive Proteome and Transcriptome Studies Reveal RNA
Processing Dysfunction in Alzheimer's disease
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Analysis of the EF24-modulated signaling pathways for thedevelopment of novel cancer combination therapies
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Signaling and Regulation of Protease-Activated Receptors 1 and 2
(PAR1 and PAR2)
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Stereospecificity of the prosocial and neurotoxic effects of
3,4-methylenedioxymethamphetamine (MDMA) in mice
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Role of Hydrogen Peroxide in the Development of Abdominal Aortic
Aneurysms
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The Effect of Ethanol Consumption on Pulmonary Macrophage
Maturation and Function
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Progesterone in the Treatment of Transient Ischemic Stroke: A
Dose-Response Study
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Two for one: The glucocorticoid receptor as a DNA- and RNA-binding
protein
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The Prosocial Effects of 3, 4-methylenedioxymethamphetamine (MDMA) in Squirrel Monkeys
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Functional Analysis of a De Novo Missense GRIN1 Mutation Associated with Intractable Seizures
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Investigation and Modeling of Binding Modes of Novel Small-Molecule
Nox2 Inhibitors
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Trafficking and Signaling of Parkin-AssociatedEndothelin-Like Receptor GPR37
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Identifying Novel Therapeutic Strategies for Enhancing Social
Cognition Using Functional Animal Models
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The Transitional States of Drug Addiction in Rhesus Monkeys
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Molecular Basis of NMDA Receptor Allosteric Regulation by New
Subunit-selective Modulators
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