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The Design, Synthesis, and Biological Evaluation of Novel Prodrugs and Antiviral Agents for HIV and Other Chronic Viral Infections
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Site-selective and Stereoselective Functionalization of Non-Activated C–H Bond
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Structure-Activity Relationship and Quantitative Structure-Activity Relationship of GluN2C/D Subunit Selective Antagonists of the N-Methyl-D-Aspartate Receptor
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Natural and Synthetic Compounds as Tools to Overcome Antibiotic Resistance
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Synthesis of small molecule therapeutics and ligands utilizing rhodium carbenoid chemistry
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Chemical Approaches to Elucidate Novel Facets of Nucleic Acid Metabolism and Signaling
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Part I: Measles virus entry into cells and the inhibition offusion and replicationPart II: The nature of cyclostreptin's interaction withmicrotubules
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SYNTHETIC AND QUANTUM-CHEMICAL EXPLORATION OF THE SELECTIVITY OF
DONOR/ACCEPTOR-SUBSTITUTED METALLOCARBENOIDS
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Part 1: Synthesis and Anti-HIV Activity of Novel CyclobutylNucleoside and Nucleotide Analogs, Part 2: Synthesis of FluorescentNucleoside Analogs, Part 3: Synthesis of Abacavir
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Synthetic Studies for Heterocycle Synthesis Part I:
Intra/intermolecular Olefin Diamination for the Stereoselective
Synthesis of 3-Aminopiperidines Part II: Total Synthesis of
Malagashanine and Synthetic Studies Toward Related Alkaloids
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Expanding the Scope of Donor/Acceptor Rhodium-Carbene Chemistry
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Design, Synthesis, and Utilization of Iridium(III)
Bis(oxazolinyl)phenyl and Iridium(III) Bis(imidazolinyl)phenyl
Complexes for Catalytic Enantioselective Atom Transfer C-H
Functionalization
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TRANSITION METAL CATALYZED STEREOSELECTIVE TRANSFORMATIONS OF
ALKYNES AND DONOR/ACCEPTOR CARBENOIDS
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I. Self-Assembly of Thioether-Modified Cationic Surfactants
II. Electrostatic Binding among Equilibrating 2-D and 3-D
Self-Assemblies
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EXPLORATION OF HIGH SYMMETRY DIRHODIUM CATALYSTS AND THE REACTION
OF DONOR/ACCEPTOR CARBENOIDS WITH ALCOHOLS
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Design, Synthesis, and Biological Evaluation of Subunit
Selective N-Methyl-D-Aspartate Receptor Modulators
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Chapter 1. Total synthesis of Fumonisin B1 Chapter 2.
Synthesis of Unnatural Sphingolipids: 1-deoxy-5-hydroxysphinganine
and its diastereomers Chapter 3. Development of Methodology:
Synthesis of cis- and trans-homoallylic alcohols
Chapter 4. Human Milk Oligosaccharides: Synthesis of Natural and
Unnatural oligomers
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The Design, Synthesis, and Biological Evaluation of Subunit-selective N-Methyl-D-Aspartate Receptor Potentiators
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Concise Total Synthesis of (-)-D-erythro-Sphingosine and Sphingosine-1-Phosphate
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Copper-Catalyzed C-N Bond Formation from Ketoxime O-Carboxylates and Application to Pyridine Synthesis
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Desulfitative Coupling Reactions for the Mild Construction of Carbon-Carbon, Carbon-Nitrogen, and Carbon-Oxygen Bonds
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Towards the Synthesis of Marine Polyether Triterpenes
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Part I: Synthesis of Cyclobutyl
Nucleoside Analogs That Mimic AZT for Inhibition of the K65R HIV-1
Reverse Transcriptase Mutant
Part II: Synthesis and Evaluation of
Truncated Triptolide Analogs to Suppress Chronic Inflammation
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Part 1. Discovery of a Fluorinated Enigmol Analog with Enhanced Pharmacokinetic and Anti-Tumor Properties. Part 2. Preferential Activation of Metabotropic Glutamate Receptor 3 over Metabotropic Glutamate Receptor 2
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Expanding the Scope of Donor/Acceptor Carbenes and the Synthesis of
Novel Therapeutic Agents for Cocaine Abuse
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Modular Synthesis of Polyketide Natural Products: Synthesis of
the C9-C27 Degradation Product of Aflastatin A and Total Synthesis
of Fostriecin
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Development of a Copper Catalyzed Aminoacetoxylation Reaction of
Olefins, Development of an Intermolecular and Diastereoselective
Iminium Cascade Reaction and Studies Towards the Synthesis of a
Malagasy Alkaloid
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Discovery and Synthesis of Next Generation Chemokine Modulators with or without Concurrent HIV Reverse Transcriptase Inhibitory Activity
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Synthesis of 2'-Fluoro-2',3'-Dideoxynucleosides as Inhibitors of
Hepatitis C Virus RNA-Dependent RNA Polymerase; Synthesis of
Cyclobutyl Phosphonate and Phosphoramidate Prodrugs for Inhibition
of HIV Reverse Transcriptase
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Stereocontrolled Synthesis of Ketones bearing Stereogenic Centers
by Desulfitative Cross-Coupling of Thiol Esters and Organostannanes
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Chapter 1: The development of a model system for the B-ring of
brevenal and methods for the formation of seven-membered rings.
Chapter 2: Iterative alkyne-epoxide cross-couplings toward the
total synthesis of PM toxin A. Chapter 3: The development of
synthons for 1,3-dimethylallylation of aldehydes.
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Synthesis and Anti-Viral Activity of Novel 3,6-dioxa-[3.2.0]bicyclonucleoside Nucleotide Analogs
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In Situ Kinetic Studies of Reactions Involving Dirhodium(II)
Donor/Acceptor Carbenes
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Investigation of C-H Bond Oxidation Reactions: I. Asymmetric
Amination of C-H Bonds Using Ruthenium(II) Catalysts II.
Investigation of Structural Determinants of Monoamine Oxidase B
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Part I: Synthesis of Cyclobutyl Nucleoside and NucleotideAnalogues as HIV-1 Reverse Transcriptase InhibitorsPart II: Improvement of Glycosylation Regioselectivity in PurineNucleoside Analogue SynthesisPart III: Enantioselective Synthesis ofβ-D-Dioxolane-T andβ-D-FDOC
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Organometallic Scaffolding as a Practical Approach toDiversity-Oriented Synthesis: Stereo- and RegiocontrolledSequential Functionalization of Pyranylalkylidene AllylmolybdenumComplexes
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Utilization of a Michael Addition-Dipolar Cycloaddition Cascade Involving 2,3- bis(Phenylsulfonyl)butadiene for Alkaloid Synthesis
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Developing Chiral Synthons for Polyketide-Based Natural Product Synthesis via Stereospecific Oxonia-Cope Rearrangement
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Metal Mediated Cross-Coupling Reactions for Carbon-Carbon andCarbon-Nitrogen Bonds Formation under Neutral pH Conditions
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Explorations of Metallocarbene and Metallonitrene Reactive
Intermediate Chemistry for the Development of Synthetically Useful
New Reactions
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Synthesis of Altromycin and Kidamycin Aglycones from a Common Intermediate & Studies towards the Total Synthesis of Kidamycin
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I. Addressing the Regioselectivity Problem in Organic Synthesis.II. A-B-A-B-A Block Amphiphiles. Balance between Hydrophilic andHydrophobic Segmentation.
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Chapter 1. Part 1: Novel Synthesis and Biological Evaluation of1,5-Linked D-Mannoseptanosides. Part 2: Synthesis ofD-Glucoseptanosides Chapter 2. Biomimetic Total Synthesis of theProposed Structure of ent-Muzitone
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Rhodium(II)-Catalyzed Asymmetric Transformations and Their
Applications in The Development of Novel CNS Drug Candidates
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SYNTHESIS OF CYCLOPROPANES AND DIHYDROFURANS BY METAL CARBENOID
REACTIONS
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Chapter 1. Biomimetic Total Synthesis of ent-Durgamone, ent-Nakorone and ent-Abudinol B Chapter 2. Biomimetic Synthesis of Fused Polypyrans
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Aerobic, Medal Mediated Ketone Synthesis from Thiol Esters and Boronic Acids
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Part I: Conformational Analysis of Bioactive Molecules inSolutionPart II: Structure-Based Design of Selective Inhibitors ofCyclin-Dependent Kinase 7
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Rhodium Alkenylcarbenes: Novel Reactivity and Precursors
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Ambient Temperature Synthesis of High Enantiopurity N-ProtectedPeptidyl Ketone by Desulfitative Cross Coupling of Peptidyl ThiolEsters and Boronic Acids
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Exploring Catalytic Properties of Polyoxometalates in Aerobic
Decontamination and Water Oxidation
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Practical Enhancement and Applications of Dirhodium Catalyzed Reactions of Donor/Acceptor Carbenes
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Design, Synthesis, and Biological Evaluation of Subunit-Selective
N-Methyl-D-Aspartate Receptor Antagonists
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The Polyoxometalate / NOx / Brx Catalystsfor Aerobic Sulfoxidations
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Mild Amide and Peptide Constructions by the Condensation of
O-Silylthionoesters with Amines and Metal Mediated Cross-Coupling
Reactions for Carbon-Carbon Bond Formation
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Computational Studies of Ligand Protein Interactions Part I: TheT-Taxol Conformation Part II: Elucidating Interdependent BindingSites on Tubulin
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Synthesis of Those Sectors of Saccharomicin A and B ContainingSaccharosamine and the Discovery of a Novel 4-H-1,3-OxazineSynthesis
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Part 1: Stereoselective Synthesis of Quaternary Center BearingAzetines and β-Amino Acid Derivatives. Part 2: Natural andEnantiomeric Progesterone Analogues for the Treatment of TraumaticBrain Injury
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ASYMMETRIC REACTIONS OF DONOR/ACCEPTOR RHODIUM CARBENOIDS: FROM
FORMAL CYCLOADDITIONS TO C-H INSERTION
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Organometallic Enantiomeric Scaffolds in the Synthesis of
Alkaloids: I. Homo-SN2´-like Reaction/Annulative Demetallation
and the Application in the Synthesis of (+)-Isofebrifugine II.
Uncatalyzed Electrophilic C-C Bond Forming Reactions of Pyranyl and
Pyridinyl Molybdenum Complexes
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Design, Synthesis, and Biologic Evaluation of
Tetrahydroisoquinoline-Based CXCR4 Modulators
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Chiral dirhodium catalysts design, synthesis and application in
asymmetric carbenoid transformations and silver-catalysis of
vinylogous fluorination
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Synthesis and Characterization of Unusal Amphiphiles Part I. Nonsteroidal Facial Amphiphiles Part II. Diketopiperazine Derived Surfactants
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Design, Synthesis, and Biological Evaluation of Subunit-Selective
N-Methyl-D-Aspartate Receptor Modulators
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RHODIUM CATALYZED ASYMMETRIC TRANSFORMATIONS OF VINYLCARBENOIDS
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Application of IMDAF and Rh(II)-Catalyzed Cascade Reactions forTotal Synthesis of Natural Products
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Development of a Novel Cascade Cyclization Reaction and its
Application Towards the Total Synthesis of Malagashanine: A
Chloroquine Efflux Inhibitor
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Design and Development of Novel Methods for C-H Functionalization
for Amination and C-C Bond Formation
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CYCLOADDITIONS AND YLIDE CHEMISTRY OF DONOR/ACCEPTOR- SUBSTITUTED
CARBENES FROM THERMAL DECOMPOSITION OF ARYLDIAZOCARBONYL COMPOUNDS
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Studies toward the total synthesis of altromycin natural products
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Navigating the Roads to Drug Discovery: Part 1: Design, Synthesis,
and Biological Evaluation of a Novel Class of Allosteric Modulators
of N-Methyl-D-Aspartate Receptor Function Part 2: Discovery of
Novel Tetrahydroisoquinoline (THIQ)-Based CXCR4 Antagonists and
Conformational Analysis of Structurally Similar CXCR4 Antagonists
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Design, Synthesis and Biological Evaluation of C4-C9 Bridged
Epothilone Analogs
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Enantiomeric Scaffolds. Molybdenum Pyranyl π-Complexes for the Asymmetric Construction of Oxa-Heterocycles
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Part I: Design, Synthesis and Biological Evaluation of C6-C8 Bridged Epothilone AnalogsPart II: Discovery of Small Molecule CXCR4 Antagonists
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Metallonitrene/Alkyne Cascade Reactions: Development of a
Versatile Process for Organic Synthesis
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Use of Furans as Vehicles for Heterocyclic Synthesis: Anaza-Achmatowicz Approach to Piperidine Alkaloids, a Novel OxidativeRoute to Acyloxypyrrolinones, and IMDAF Studies Toward a Synthesisof Minfiensine and Morphine
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Investigations of exo-Mode Oxacyclizations for the Synthesis of
Cyclic Ethers
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Exo-mode oxacyclization strategies for synthesis of
trans-fused polycyclic ethers: the ABC ring sector of
brevenal
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Synthetic Studies Toward Methanoquinolizidine-Containing
Akuammiline Alkaloids
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Towards the Development of Non-Toxic Therapeutics in the Fight
Against Cancer
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Development of Transition Metal Catalyzed Metallonitrene and Metallocarbene Group Transfer Reactions
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SYNTHESIS OF SMALL MOLECULE THERAPEUTICS UTILIZING RHODIUM
CARBENOID CHEMISTRY
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Promysalin and CD437: Compounds Investigating New Antibacterial Mechanisms
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The Design, Synthesis, and Biological Evaluation of Subunit-Selective Modulators of the N-Methyl-D-Aspartate Receptor
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Synthesis of bulky 1,4,7-triazacylcononanes, including asymmetric derivatives; Esterification by aryl-diselenide catalyzed redox condensation; 1-amino-3,4-difluorocyclopentane-1-carboxylic acids as PET imaging agents
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The Development of Complementary Allylic C-H Amination and Amidation Conditions for the Regioselective Functionalization of Group IX MCp*-π-Allyl Intermediates
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The Synthesis and Application of a Series of C4-Symmetric Dirhodium Catalysts Derived from 1-(2-Chlorophenyl)-2,2-Diphenylcyclopropanecarboxylate Ligands
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Complementary Approaches to Combat Antibacterial Resistance: Metal-binding Small Molecules and Quaternary Ammonium Compounds
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Structure, Synthesis, and Reactivity: Intentional Design Approaches to Agonists for Liver Receptor Homolog-1 and Photochemical Arene Dearomatization
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Carolacton and Honokiol: using natural product inspiration to target the oral microbiome
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Synthesis, Structure-Activity Relationship, and Biological Evaluation of Subunit-Selective NMDA Receptor Modulators
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Reductive Processes Enabled by Photoredox for the Synthesis and Modification of Pharmaceutically Relevant Molecules
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Development of Intermolecular Couplings of Aryl Radical Species with Olefins
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Radical Conjugate Addition of N-Heterocycles and Tertiary Amines
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Development and Applications of a New Dirhodium(II) Tetracarboxylate Catalyst and Asymmetric Cyclopropanation of Heterocyclic Compounds
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Exploring the Influence of Dirhodium Catalyst Structure on the Regio- and Stereoselectivity Properties of Donor/Acceptor Carbenes
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Allylic C-H Arylation, Enantioselective Catalyst Development, and Enantioselective Allylic C-H Amidation
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Broadening the applications of rhodium donor/acceptor carbene mediated C–H functionalization
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Harnessing the Dual Nature of Peptide Nucleic Acids
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Studies Towards the Synthesis of Malagasy Alkaloids, and Development and Applications of Regio- and Enantioselective Group IX Metal-Catalysed Reactions
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