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SYNTHETIC AND QUANTUM-CHEMICAL EXPLORATION OF THE SELECTIVITY OF
DONOR/ACCEPTOR-SUBSTITUTED METALLOCARBENOIDS
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Synthetic Studies for Heterocycle Synthesis Part I:
Intra/intermolecular Olefin Diamination for the Stereoselective
Synthesis of 3-Aminopiperidines Part II: Total Synthesis of
Malagashanine and Synthetic Studies Toward Related Alkaloids
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Expanding the Scope of Donor/Acceptor Rhodium-Carbene Chemistry
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EXPLORATION OF HIGH SYMMETRY DIRHODIUM CATALYSTS AND THE REACTION
OF DONOR/ACCEPTOR CARBENOIDS WITH ALCOHOLS
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TRANSITION METAL CATALYZED STEREOSELECTIVE TRANSFORMATIONS OF
ALKYNES AND DONOR/ACCEPTOR CARBENOIDS
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Design, Synthesis, and Utilization of Iridium(III)
Bis(oxazolinyl)phenyl and Iridium(III) Bis(imidazolinyl)phenyl
Complexes for Catalytic Enantioselective Atom Transfer C-H
Functionalization
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I. Self-Assembly of Thioether-Modified Cationic Surfactants
II. Electrostatic Binding among Equilibrating 2-D and 3-D
Self-Assemblies
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Chapter 1. Total synthesis of Fumonisin B1 Chapter 2.
Synthesis of Unnatural Sphingolipids: 1-deoxy-5-hydroxysphinganine
and its diastereomers Chapter 3. Development of Methodology:
Synthesis of cis- and trans-homoallylic alcohols
Chapter 4. Human Milk Oligosaccharides: Synthesis of Natural and
Unnatural oligomers
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Design, Synthesis, and Biological Evaluation of Subunit
Selective N-Methyl-D-Aspartate Receptor Modulators
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I. A New Approach to the Synthesis of a Key 5-Oxo-Pyridinyl
Molybdenum Scaffold. II. Oxidative Demetalation of
η3-Allylmolybdenum Complexes with an Oxygen
Nucleophile; Application to the Synthesis of (+)-Isofebrifugine
Analogs
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Expanding the Scope of Donor/Acceptor Carbenes and the Synthesis of
Novel Therapeutic Agents for Cocaine Abuse
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Part I: Synthesis of Cyclobutyl
Nucleoside Analogs That Mimic AZT for Inhibition of the K65R HIV-1
Reverse Transcriptase Mutant
Part II: Synthesis and Evaluation of
Truncated Triptolide Analogs to Suppress Chronic Inflammation
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Modular Synthesis of Polyketide Natural Products: Synthesis of
the C9-C27 Degradation Product of Aflastatin A and Total Synthesis
of Fostriecin
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Development of a Copper Catalyzed Aminoacetoxylation Reaction of
Olefins, Development of an Intermolecular and Diastereoselective
Iminium Cascade Reaction and Studies Towards the Synthesis of a
Malagasy Alkaloid
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TARGETING MIXED LINEAGE LEUKEMIA AS ANTICANCER THERAPY FOR
INFANTILE ACUTE LYMPHOBLASTIC LEUKEMIA THROUGH THE SYNTHESIS OF
NOVEL COMPOUNDS
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Stereocontrolled Synthesis of Ketones bearing Stereogenic Centers
by Desulfitative Cross-Coupling of Thiol Esters and Organostannanes
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Chapter 1: The development of a model system for the B-ring of
brevenal and methods for the formation of seven-membered rings.
Chapter 2: Iterative alkyne-epoxide cross-couplings toward the
total synthesis of PM toxin A. Chapter 3: The development of
synthons for 1,3-dimethylallylation of aldehydes.
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Synthesis of 2'-Fluoro-2',3'-Dideoxynucleosides as Inhibitors of
Hepatitis C Virus RNA-Dependent RNA Polymerase; Synthesis of
Cyclobutyl Phosphonate and Phosphoramidate Prodrugs for Inhibition
of HIV Reverse Transcriptase
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In Situ Kinetic Studies of Reactions Involving Dirhodium(II)
Donor/Acceptor Carbenes
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Investigation of C-H Bond Oxidation Reactions: I. Asymmetric
Amination of C-H Bonds Using Ruthenium(II) Catalysts II.
Investigation of Structural Determinants of Monoamine Oxidase B
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Explorations of Metallocarbene and Metallonitrene Reactive
Intermediate Chemistry for the Development of Synthetically Useful
New Reactions
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Progress Toward the Total Synthesis of PM-toxin A And Future
Development of Mild Lewis Acid Activated Alkynylation of Epoxides
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Rhodium(II)-Catalyzed Asymmetric Transformations and Their
Applications in The Development of Novel CNS Drug Candidates
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SYNTHESIS OF CYCLOPROPANES AND DIHYDROFURANS BY METAL CARBENOID
REACTIONS
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Part I: Design, Synthesis, and Biological Activity of NMDA
Receptor Antagonists
Part II: Design and Synthesis of Measles Virus Inhibitors
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Rhodium Alkenylcarbenes: Novel Reactivity and Precursors
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Exploring Catalytic Properties of Polyoxometalates in Aerobic
Decontamination and Water Oxidation
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Mild Amide and Peptide Constructions by the Condensation of
O-Silylthionoesters with Amines and Metal Mediated Cross-Coupling
Reactions for Carbon-Carbon Bond Formation
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Design, Synthesis, and Biological Evaluation of Subunit-Selective
N-Methyl-D-Aspartate Receptor Antagonists
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ASYMMETRIC REACTIONS OF DONOR/ACCEPTOR RHODIUM CARBENOIDS: FROM
FORMAL CYCLOADDITIONS TO C-H INSERTION
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Organometallic Enantiomeric Scaffolds in the Synthesis of
Alkaloids: I. Homo-SN2´-like Reaction/Annulative Demetallation
and the Application in the Synthesis of (+)-Isofebrifugine II.
Uncatalyzed Electrophilic C-C Bond Forming Reactions of Pyranyl and
Pyridinyl Molybdenum Complexes
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Design, Synthesis, and Biologic Evaluation of
Tetrahydroisoquinoline-Based CXCR4 Modulators
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Chiral dirhodium catalysts design, synthesis and application in
asymmetric carbenoid transformations and silver-catalysis of
vinylogous fluorination
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Design, Synthesis, and Biological Evaluation of Subunit-Selective
N-Methyl-D-Aspartate Receptor Modulators
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RHODIUM CATALYZED ASYMMETRIC TRANSFORMATIONS OF VINYLCARBENOIDS
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Development of a Novel Cascade Cyclization Reaction and its
Application Towards the Total Synthesis of Malagashanine: A
Chloroquine Efflux Inhibitor
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Design and Development of Novel Methods for C-H Functionalization
for Amination and C-C Bond Formation
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[5+2] Cycloadditions to Form Oxobicyclo[3.2.1]octanes
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CYCLOADDITIONS AND YLIDE CHEMISTRY OF DONOR/ACCEPTOR- SUBSTITUTED
CARBENES FROM THERMAL DECOMPOSITION OF ARYLDIAZOCARBONYL COMPOUNDS
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Ring Chain Isomerism: Ligands for Mediating Two-Electron
Reactivity with First-Row Transition Metals
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Navigating the Roads to Drug Discovery: Part 1: Design, Synthesis,
and Biological Evaluation of a Novel Class of Allosteric Modulators
of N-Methyl-D-Aspartate Receptor Function Part 2: Discovery of
Novel Tetrahydroisoquinoline (THIQ)-Based CXCR4 Antagonists and
Conformational Analysis of Structurally Similar CXCR4 Antagonists
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Design, Synthesis and Biological Evaluation of C4-C9 Bridged
Epothilone Analogs
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A menthol derived synthon for preparing homoallylic alcohols
bearing three contiguous elements of stereochemistry and Progress
towards a synthon with two centers of reactivity for the allylation
of two different aldehydes
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Metallonitrene/Alkyne Cascade Reactions: Development of a
Versatile Process for Organic Synthesis
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Exo-mode oxacyclization strategies for synthesis of
trans-fused polycyclic ethers: the ABC ring sector of
brevenal
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Synthetic Studies Toward Cyclobutyl Nucleoside Analogs for the
Treatment of Hepatitis C Virus
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Investigations of exo-Mode Oxacyclizations for the Synthesis of
Cyclic Ethers
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Synthetic Studies Toward Methanoquinolizidine-Containing
Akuammiline Alkaloids
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Towards the Development of Non-Toxic Therapeutics in the Fight
Against Cancer
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Synthesis of 3-Methyl-TpMo(CO)2(5-Oxo-Pyranyl)
Organometallic Scaffold and Its Application in Forming Quaternary
Center at a Ring Junction via an Oxidative
Annulation-Demetalation Cascade
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Development of a novel stereo-selective synthetic route towards
Pumiliotoxin C, potent neurotoxin, via asymmetric
Diels-Alder and sequential protonation-nucleophilic addition as key
reaction steps
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Synthesis and Excited State Dynamics of Oligothiophene-Nitronyl
Nitroxides
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SYNTHESIS OF SMALL MOLECULE THERAPEUTICS UTILIZING RHODIUM
CARBENOID CHEMISTRY
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Use of Furans as Vehicles for Heterocyclic Synthesis: Anaza-Achmatowicz Approach to Piperidine Alkaloids, a Novel OxidativeRoute to Acyloxypyrrolinones, and IMDAF Studies Toward a Synthesisof Minfiensine and Morphine
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I. Organometallic Enantiomeric Scaffolding: Total Synthesis of(-)-Adaline and (-)-Adalinine Using a Key 5-Oxo-PyridinylMolybdenum Scaffold and Featuring a SemipinacolRearrangment/1,5-"Michael-like" Sequence.II. Exchange Reactions of 1-Alkoxy and 1-Sulfonyloxy 3-AllylMolybdenum Complexes
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Part I: Design, Synthesis and Biological Evaluation of C6-C8 Bridged Epothilone AnalogsPart II: Discovery of Small Molecule CXCR4 Antagonists
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Enantiomeric Scaffolds. Molybdenum Pyranyl π-Complexes for the Asymmetric Construction of Oxa-Heterocycles
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Studies toward the total synthesis of altromycin natural products
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Application of IMDAF and Rh(II)-Catalyzed Cascade Reactions forTotal Synthesis of Natural Products
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Synthesis and Characterization of Unusal Amphiphiles Part I. Nonsteroidal Facial Amphiphiles Part II. Diketopiperazine Derived Surfactants
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Part 1: Stereoselective Synthesis of Quaternary Center BearingAzetines and β-Amino Acid Derivatives. Part 2: Natural andEnantiomeric Progesterone Analogues for the Treatment of TraumaticBrain Injury
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Synthesis of Those Sectors of Saccharomicin A and B ContainingSaccharosamine and the Discovery of a Novel 4-H-1,3-OxazineSynthesis
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Computational Studies of Ligand Protein Interactions Part I: TheT-Taxol Conformation Part II: Elucidating Interdependent BindingSites on Tubulin
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The Polyoxometalate / NOx / Brx Catalystsfor Aerobic Sulfoxidations
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Ambient Temperature Synthesis of High Enantiopurity N-ProtectedPeptidyl Ketone by Desulfitative Cross Coupling of Peptidyl ThiolEsters and Boronic Acids
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Part I: Conformational Analysis of Bioactive Molecules inSolutionPart II: Structure-Based Design of Selective Inhibitors ofCyclin-Dependent Kinase 7
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Aerobic, Medal Mediated Ketone Synthesis from Thiol Esters and Boronic Acids
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Chapter 1. Biomimetic Total Synthesis of ent-Durgamone, ent-Nakorone and ent-Abudinol B Chapter 2. Biomimetic Synthesis of Fused Polypyrans
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Chapter 1. Part 1: Novel Synthesis and Biological Evaluation of1,5-Linked D-Mannoseptanosides. Part 2: Synthesis ofD-Glucoseptanosides Chapter 2. Biomimetic Total Synthesis of theProposed Structure of ent-Muzitone
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I. Addressing the Regioselectivity Problem in Organic Synthesis.II. A-B-A-B-A Block Amphiphiles. Balance between Hydrophilic andHydrophobic Segmentation.
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Synthesis of Altromycin and Kidamycin Aglycones from a Common Intermediate & Studies towards the Total Synthesis of Kidamycin
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Metal Mediated Cross-Coupling Reactions for Carbon-Carbon andCarbon-Nitrogen Bonds Formation under Neutral pH Conditions
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Developing Chiral Synthons for Polyketide-Based Natural Product Synthesis via Stereospecific Oxonia-Cope Rearrangement
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Utilization of a Michael Addition-Dipolar Cycloaddition Cascade Involving 2,3- bis(Phenylsulfonyl)butadiene for Alkaloid Synthesis
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Organometallic Scaffolding as a Practical Approach toDiversity-Oriented Synthesis: Stereo- and RegiocontrolledSequential Functionalization of Pyranylalkylidene AllylmolybdenumComplexes
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Part I: Synthesis of Cyclobutyl Nucleoside and NucleotideAnalogues as HIV-1 Reverse Transcriptase InhibitorsPart II: Improvement of Glycosylation Regioselectivity in PurineNucleoside Analogue SynthesisPart III: Enantioselective Synthesis ofβ-D-Dioxolane-T andβ-D-FDOC
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Synthesis and Anti-Viral Activity of Novel 3,6-dioxa-[3.2.0]bicyclonucleoside Nucleotide Analogs
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Towards the Synthesis of Marine Polyether Triterpenes
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Copper-Catalyzed C-N Bond Formation from Ketoxime O-Carboxylates and Application to Pyridine Synthesis
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Concise Total Synthesis of (-)-D-erythro-Sphingosine and Sphingosine-1-Phosphate
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Part 1: Synthesis and Anti-HIV Activity of Novel CyclobutylNucleoside and Nucleotide Analogs, Part 2: Synthesis of FluorescentNucleoside Analogs, Part 3: Synthesis of Abacavir
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Part I: Measles virus entry into cells and the inhibition offusion and replicationPart II: The nature of cyclostreptin's interaction withmicrotubules
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Development of a Redox-Active Ligand Framework: A Novel Approach towards Reactivity in C−H Functionalization Reactions
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Investigating Sustainable Precious Metal Catalysis: Routine Dirhodium Catalyzed Carbene Reactions with High Yield and Enantioselectivity at Low Loadings
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The Catalytic Aerobic Oxidation of Aldehyde and Alcohol Substrates with Redox-Active Ligand-Supported Earth-Abundant Metal Catalysts
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Expanding the scope of donor/acceptor rhodium-carbene chemistry
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Development of Transition Metal Catalyzed Metallonitrene and Metallocarbene Group Transfer Reactions
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Synthesis and Reactivity of Benzo[1,3,2]dithiazole 1,1-dioxides: Implications in Acylative Redox Dehydration
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Practical Enhancement and Applications of Dirhodium Catalyzed Reactions of Donor/Acceptor Carbenes
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Discovery and Synthesis of Next Generation Chemokine Modulators with or without Concurrent HIV Reverse Transcriptase Inhibitory Activity
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Modular Synthesis of Asymmetric Triazacyclononane Derivatives and Potential Aerobic Copper Oxidation Catalyst Supported by a Bridging Bulky Triazacyclononane
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Part 1. Discovery of a Fluorinated Enigmol Analog with Enhanced Pharmacokinetic and Anti-Tumor Properties. Part 2. Preferential Activation of Metabotropic Glutamate Receptor 3 over Metabotropic Glutamate Receptor 2
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Acylative Redox Dehydration of Carboxylic Acids and Benzoisothiazolones in the Synthesis of Thioesters with Triethylphosphite as a Terminal Reductant
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Desulfitative Coupling Reactions for the Mild Construction of Carbon-Carbon, Carbon-Nitrogen, and Carbon-Oxygen Bonds
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The Design, Synthesis, and Biological Evaluation of Subunit-selective N-Methyl-D-Aspartate Receptor Potentiators
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Cobalt Catalyzed Intramolecular Cyclization of Acyclic Alkenols for Polycyclic Ether Synthesis
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Chemical Approaches to Elucidate Novel Facets of Nucleic Acid Metabolism and Signaling
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Synthesis of 18F-PET-sensitive Agents for Targeted Visualization of Brain Tumors
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Carolacton and Honokiol: using natural product inspiration to target the oral microbiome
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Reductive Processes Enabled by Photoredox for the Synthesis and Modification of Pharmaceutically Relevant Molecules
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