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McDonald, Frank, Emory University
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Dissertation
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TOTAL SYNTHESIS AND BIOLOGICAL EVALUATION OF NATURAL PRODUCT MIMICS TOWARDS FUNGAL PATHOGENS
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Synthetic Studies Toward Methanoquinolizidine-Containing
Akuammiline Alkaloids
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Exo-mode oxacyclization strategies for synthesis of
trans-fused polycyclic ethers: the ABC ring sector of
brevenal
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Investigations of exo-Mode Oxacyclizations for the Synthesis of
Cyclic Ethers
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Metallonitrene/Alkyne Cascade Reactions: Development of a
Versatile Process for Organic Synthesis
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Part I: Design, Synthesis and Biological Evaluation of C6-C8 Bridged Epothilone AnalogsPart II: Discovery of Small Molecule CXCR4 Antagonists
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Enantiomeric Scaffolds. Molybdenum Pyranyl π-Complexes for the Asymmetric Construction of Oxa-Heterocycles
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Navigating the Roads to Drug Discovery: Part 1: Design, Synthesis,
and Biological Evaluation of a Novel Class of Allosteric Modulators
of N-Methyl-D-Aspartate Receptor Function Part 2: Discovery of
Novel Tetrahydroisoquinoline (THIQ)-Based CXCR4 Antagonists and
Conformational Analysis of Structurally Similar CXCR4 Antagonists
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Studies toward the total synthesis of altromycin natural products
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Development of a Novel Cascade Cyclization Reaction and its
Application Towards the Total Synthesis of Malagashanine: A
Chloroquine Efflux Inhibitor
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Application of IMDAF and Rh(II)-Catalyzed Cascade Reactions forTotal Synthesis of Natural Products
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Synthesis and Characterization of Unusal Amphiphiles Part I. Nonsteroidal Facial Amphiphiles Part II. Diketopiperazine Derived Surfactants
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Part 1: Stereoselective Synthesis of Quaternary Center BearingAzetines and β-Amino Acid Derivatives. Part 2: Natural andEnantiomeric Progesterone Analogues for the Treatment of TraumaticBrain Injury
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Synthesis of Those Sectors of Saccharomicin A and B ContainingSaccharosamine and the Discovery of a Novel 4-H-1,3-OxazineSynthesis
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Mild Amide and Peptide Constructions by the Condensation of
O-Silylthionoesters with Amines and Metal Mediated Cross-Coupling
Reactions for Carbon-Carbon Bond Formation
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Design, Synthesis, and Biological Evaluation of Subunit-Selective
N-Methyl-D-Aspartate Receptor Antagonists
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Practical Enhancement and Applications of Dirhodium Catalyzed Reactions of Donor/Acceptor Carbenes
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Chapter 1. Biomimetic Total Synthesis of ent-Durgamone, ent-Nakorone and ent-Abudinol B Chapter 2. Biomimetic Synthesis of Fused Polypyrans
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SYNTHESIS OF CYCLOPROPANES AND DIHYDROFURANS BY METAL CARBENOID
REACTIONS
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Chapter 1. Part 1: Novel Synthesis and Biological Evaluation of1,5-Linked D-Mannoseptanosides. Part 2: Synthesis ofD-Glucoseptanosides Chapter 2. Biomimetic Total Synthesis of theProposed Structure of ent-Muzitone
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Synthesis of Altromycin and Kidamycin Aglycones from a Common Intermediate & Studies towards the Total Synthesis of Kidamycin
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Explorations of Metallocarbene and Metallonitrene Reactive
Intermediate Chemistry for the Development of Synthetically Useful
New Reactions
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Developing Chiral Synthons for Polyketide-Based Natural Product Synthesis via Stereospecific Oxonia-Cope Rearrangement
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Utilization of a Michael Addition-Dipolar Cycloaddition Cascade Involving 2,3- bis(Phenylsulfonyl)butadiene for Alkaloid Synthesis
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Organometallic Scaffolding as a Practical Approach toDiversity-Oriented Synthesis: Stereo- and RegiocontrolledSequential Functionalization of Pyranylalkylidene AllylmolybdenumComplexes
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In Situ Kinetic Studies of Reactions Involving Dirhodium(II)
Donor/Acceptor Carbenes
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Chapter 1: The development of a model system for the B-ring of
brevenal and methods for the formation of seven-membered rings.
Chapter 2: Iterative alkyne-epoxide cross-couplings toward the
total synthesis of PM toxin A. Chapter 3: The development of
synthons for 1,3-dimethylallylation of aldehydes.
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Stereocontrolled Synthesis of Ketones bearing Stereogenic Centers
by Desulfitative Cross-Coupling of Thiol Esters and Organostannanes
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Modular Synthesis of Polyketide Natural Products: Synthesis of
the C9-C27 Degradation Product of Aflastatin A and Total Synthesis
of Fostriecin
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Part I: Synthesis of Cyclobutyl
Nucleoside Analogs That Mimic AZT for Inhibition of the K65R HIV-1
Reverse Transcriptase Mutant
Part II: Synthesis and Evaluation of
Truncated Triptolide Analogs to Suppress Chronic Inflammation
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Towards the Synthesis of Marine Polyether Triterpenes
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Desulfitative Coupling Reactions for the Mild Construction of Carbon-Carbon, Carbon-Nitrogen, and Carbon-Oxygen Bonds
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Copper-Catalyzed C-N Bond Formation from Ketoxime O-Carboxylates and Application to Pyridine Synthesis
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The Design, Synthesis, and Biological Evaluation of Subunit-selective N-Methyl-D-Aspartate Receptor Potentiators
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Chapter 1. Total synthesis of Fumonisin B1 Chapter 2.
Synthesis of Unnatural Sphingolipids: 1-deoxy-5-hydroxysphinganine
and its diastereomers Chapter 3. Development of Methodology:
Synthesis of cis- and trans-homoallylic alcohols
Chapter 4. Human Milk Oligosaccharides: Synthesis of Natural and
Unnatural oligomers
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TRANSITION METAL CATALYZED STEREOSELECTIVE TRANSFORMATIONS OF
ALKYNES AND DONOR/ACCEPTOR CARBENOIDS
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Design, Synthesis, and Utilization of Iridium(III)
Bis(oxazolinyl)phenyl and Iridium(III) Bis(imidazolinyl)phenyl
Complexes for Catalytic Enantioselective Atom Transfer C-H
Functionalization
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Expanding the Scope of Donor/Acceptor Rhodium-Carbene Chemistry
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Synthetic Studies for Heterocycle Synthesis Part I:
Intra/intermolecular Olefin Diamination for the Stereoselective
Synthesis of 3-Aminopiperidines Part II: Total Synthesis of
Malagashanine and Synthetic Studies Toward Related Alkaloids
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Part 1: Synthesis and Anti-HIV Activity of Novel CyclobutylNucleoside and Nucleotide Analogs, Part 2: Synthesis of FluorescentNucleoside Analogs, Part 3: Synthesis of Abacavir
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The Design, Synthesis, and Biological Evaluation of Novel Prodrugs and Antiviral Agents for HIV and Other Chronic Viral Infections
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