Search Constraints
« Previous |
1 - 50 of 61
|
Next »
Search Results
Select an image to start the slideshow
The Design, Synthesis, and Biological Evaluation of Subunit-selective N-Methyl-D-Aspartate Receptor Potentiators
1 of 50
Acylative Redox Dehydration of Carboxylic Acids and Benzoisothiazolones in the Synthesis of Thioesters with Triethylphosphite as a Terminal Reductant
2 of 50
Part 1. Discovery of a Fluorinated Enigmol Analog with Enhanced Pharmacokinetic and Anti-Tumor Properties. Part 2. Preferential Activation of Metabotropic Glutamate Receptor 3 over Metabotropic Glutamate Receptor 2
3 of 50
Discovery and Synthesis of Next Generation Chemokine Modulators with or without Concurrent HIV Reverse Transcriptase Inhibitory Activity
4 of 50
Development of Fluorescence-based Molecular Tension Probes to Investigate Cellular Mechanical Forces
5 of 50
Part I: Measles virus entry into cells and the inhibition offusion and replicationPart II: The nature of cyclostreptin's interaction withmicrotubules
6 of 50
Part 1: Synthesis and Anti-HIV Activity of Novel CyclobutylNucleoside and Nucleotide Analogs, Part 2: Synthesis of FluorescentNucleoside Analogs, Part 3: Synthesis of Abacavir
7 of 50
Paclitaxel and Cyclostreptin in theTubulin Binding Site
8 of 50
Towards the Synthesis of Marine Polyether Triterpenes
9 of 50
Analysis of the EF24-modulated signaling pathways for thedevelopment of novel cancer combination therapies
10 of 50
Part I: Structure and Function in the NMDA Ligand Binding DomainPart II: Comparison of Paclitaxel Analogs through MolecularDynamics Simulation; Solution Conformations of Cyclic Peptides
11 of 50
Synthesis and Anti-Viral Activity of Novel 3,6-dioxa-[3.2.0]bicyclonucleoside Nucleotide Analogs
12 of 50
Part I: Synthesis of Cyclobutyl Nucleoside and NucleotideAnalogues as HIV-1 Reverse Transcriptase InhibitorsPart II: Improvement of Glycosylation Regioselectivity in PurineNucleoside Analogue SynthesisPart III: Enantioselective Synthesis ofβ-D-Dioxolane-T andβ-D-FDOC
13 of 50
Metal Mediated Cross-Coupling Reactions for Carbon-Carbon andCarbon-Nitrogen Bonds Formation under Neutral pH Conditions
14 of 50
Synthesis of Altromycin and Kidamycin Aglycones from a Common Intermediate & Studies towards the Total Synthesis of Kidamycin
15 of 50
Part I: Conformational Analysis of Bioactive Molecules inSolutionPart II: Structure-Based Design of Selective Inhibitors ofCyclin-Dependent Kinase 7
16 of 50
Computational Studies of Ligand Protein Interactions Part I: TheT-Taxol Conformation Part II: Elucidating Interdependent BindingSites on Tubulin
17 of 50
Synthesis of Those Sectors of Saccharomicin A and B ContainingSaccharosamine and the Discovery of a Novel 4-H-1,3-OxazineSynthesis
18 of 50
Part 1: Stereoselective Synthesis of Quaternary Center BearingAzetines and β-Amino Acid Derivatives. Part 2: Natural andEnantiomeric Progesterone Analogues for the Treatment of TraumaticBrain Injury
19 of 50
Synthesis and Characterization of Unusal Amphiphiles Part I. Nonsteroidal Facial Amphiphiles Part II. Diketopiperazine Derived Surfactants
20 of 50
Engineering The Substrate Specificity Of Human Deoxycytidine Kinase
21 of 50
Part I: Design, Synthesis and Biological Evaluation of C6-C8 Bridged Epothilone AnalogsPart II: Discovery of Small Molecule CXCR4 Antagonists
22 of 50
Use of Furans as Vehicles for Heterocyclic Synthesis: Anaza-Achmatowicz Approach to Piperidine Alkaloids, a Novel OxidativeRoute to Acyloxypyrrolinones, and IMDAF Studies Toward a Synthesisof Minfiensine and Morphine
23 of 50
Design, Development and Application of a Novel In-Silico
High-throughput Screening Approach
24 of 50
Multi-mechanism antiretroviral approach targeting macrophage
derived viral sanctuaries
25 of 50
SYNTHESIS OF SMALL MOLECULE THERAPEUTICS UTILIZING RHODIUM
CARBENOID CHEMISTRY
26 of 50
Part I. Design of a novel class of reversible non-covalent small
molecule inhibitors for human Granzyme B (hGrB)
Part II. Curcumin and mimics as proteasome inhibitors
Part III. Design of novel coactivator binding inhibitors (CBIs)
for the estrogen receptor α : break the 1µM barrier
27 of 50
Development of a novel stereo-selective synthetic route towards
Pumiliotoxin C, potent neurotoxin, via asymmetric
Diels-Alder and sequential protonation-nucleophilic addition as key
reaction steps
28 of 50
Towards the Development of Non-Toxic Therapeutics in the Fight
Against Cancer
29 of 50
Synthetic Studies Toward Cyclobutyl Nucleoside Analogs for the
Treatment of Hepatitis C Virus
30 of 50
Computer-Assisted Drug Discovery Part I: Design, Development,
Validation and Application of FRESH, a Novel In-Silico
High-throughput Screening Program Part II: Monocarbonyl Curcumin
Analogues: Heterocyclic Pleiotropic Kinase Inhibitors that Mediate
Anticancer Properties Part III: Development of 2nd Generation
NAMFIS Software Program by Java
31 of 50
Design, Synthesis and Biological Evaluation of C4-C9 Bridged
Epothilone Analogs
32 of 50
Navigating the Roads to Drug Discovery: Part 1: Design, Synthesis,
and Biological Evaluation of a Novel Class of Allosteric Modulators
of N-Methyl-D-Aspartate Receptor Function Part 2: Discovery of
Novel Tetrahydroisoquinoline (THIQ)-Based CXCR4 Antagonists and
Conformational Analysis of Structurally Similar CXCR4 Antagonists
33 of 50
Generating designer enzymes for therapeutic and industrial
applications
34 of 50
Application of fluorescent nucleoside analogs in direct evolution
of Drosophila melanogaster deoxyribonucleoside kinase
35 of 50
Design, Synthesis, and Biological Evaluation of Subunit-Selective
N-Methyl-D-Aspartate Receptor Modulators
36 of 50
Design, Synthesis, and Biologic Evaluation of
Tetrahydroisoquinoline-Based CXCR4 Modulators
37 of 50
Organometallic Enantiomeric Scaffolds in the Synthesis of
Alkaloids: I. Homo-SN2´-like Reaction/Annulative Demetallation
and the Application in the Synthesis of (+)-Isofebrifugine II.
Uncatalyzed Electrophilic C-C Bond Forming Reactions of Pyranyl and
Pyridinyl Molybdenum Complexes
38 of 50
ASYMMETRIC REACTIONS OF DONOR/ACCEPTOR RHODIUM CARBENOIDS: FROM
FORMAL CYCLOADDITIONS TO C-H INSERTION
39 of 50
Structural Determinants of Activity, Mechanism and Structure
Activity Relationships of Novel GluN2C/D Subunit Selective
Antagonists of the N-methyl-D-Aspartate Receptor
40 of 50
Design, Synthesis, and Biological Evaluation of Subunit-Selective
N-Methyl-D-Aspartate Receptor Antagonists
41 of 50
Rhodium Alkenylcarbenes: Novel Reactivity and Precursors
42 of 50
Inhibition of the NF-κB signaling pathway by the curcumin
analogs, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31) and
3,5-Bis(2-pyridinylmethylidene)-1-methyl-4-piperidone (UBS109):
in-vitro and in-vivo studies.
43 of 50
Validation of Receptor-Based Drug Design and Applications in the
Study of IKKs, Truncated Taxane and LRH-1
44 of 50
Part I: Design, Synthesis, and Biological Activity of NMDA
Receptor Antagonists
Part II: Design and Synthesis of Measles Virus Inhibitors
45 of 50
SYNTHESIS OF CYCLOPROPANES AND DIHYDROFURANS BY METAL CARBENOID
REACTIONS
46 of 50
Development of Monocarbonyl Curcumin Analogues Towards Treating
Tuberculosis and Cancer
47 of 50
Screening, hit expansion and mechanistic studies for natural
product analogs derived from traditional herbal medicine: curcumin
and triptolide.
48 of 50
Progress Toward the Total Synthesis of PM-toxin A And Future
Development of Mild Lewis Acid Activated Alkynylation of Epoxides
49 of 50
Use of Receptor-Based Drug Design and Applications in the Study
of finding antagonists for MD-2/TLR4, GLP and CXCR4
50 of 50