SYNTHESIS OF SMALL MOLECULE THERAPEUTICS UTILIZING RHODIUM CARBENOID CHEMISTRY

Towards the Development of Non-Toxic Therapeutics in the Fight Against Cancer

Part I: Design, Synthesis and Biological Evaluation of C6-C8 Bridged Epothilone AnalogsPart II: Discovery of Small Molecule CXCR4 Antagonists

Computer-Assisted Drug Discovery Part I: Design, Development, Validation and Application of FRESH, a Novel In-Silico High-throughput Screening Program Part II: Monocarbonyl Curcumin Analogues: Heterocyclic Pleiotropic Kinase Inhibitors that Mediate Anticancer Properties Part III: Development of 2nd Generation NAMFIS Software Program by Java

Design, Synthesis, and Biological Evaluation of Subunit-Selective N-Methyl-D-Aspartate Receptor Antagonists

Part I: Conformational Analysis of Bioactive Molecules inSolutionPart II: Structure-Based Design of Selective Inhibitors ofCyclin-Dependent Kinase 7

Part I: Design, Synthesis, and Biological Activity of NMDA Receptor Antagonists Part II: Design and Synthesis of Measles Virus Inhibitors

Use of Receptor-Based Drug Design and Applications in the Study of finding antagonists for MD-2/TLR4, GLP and CXCR4

Synthesis and Anti-Viral Activity of Novel 3,6-dioxa-[3.2.0]bicyclonucleoside Nucleotide Analogs

Synthesis of 2'-Fluoro-2',3'-Dideoxynucleosides as Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase; Synthesis of Cyclobutyl Phosphonate and Phosphoramidate Prodrugs for Inhibition of HIV Reverse Transcriptase

Part 1. Discovery of a Fluorinated Enigmol Analog with Enhanced Pharmacokinetic and Anti-Tumor Properties. Part 2. Preferential Activation of Metabotropic Glutamate Receptor 3 over Metabotropic Glutamate Receptor 2

Identification of Small Molecule Inhibitors of I-κB Kinase

Part I: Synthesis of Cyclobutyl Nucleoside Analogs That Mimic AZT for Inhibition of the K65R HIV-1 Reverse Transcriptase Mutant Part II: Synthesis and Evaluation of Truncated Triptolide Analogs to Suppress Chronic Inflammation

The Design, Synthesis, and Biological Evaluation of Subunit-selective N-Methyl-D-Aspartate Receptor Potentiators

Investigation and Modeling of Binding Modes of Novel Small-Molecule Nox2 Inhibitors

Part I: Measles virus entry into cells and the inhibition offusion and replicationPart II: The nature of cyclostreptin's interaction withmicrotubules