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Snyder, James P, Emory University
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Synthesis Towards a Constrained Paclitaxel Analog
1 de 8
Part I. Design of a novel class of reversible non-covalent small
molecule inhibitors for human Granzyme B (hGrB)
Part II. Curcumin and mimics as proteasome inhibitors
Part III. Design of novel coactivator binding inhibitors (CBIs)
for the estrogen receptor α : break the 1µM barrier
2 de 8
Computer-Assisted Drug Discovery Part I: Design, Development,
Validation and Application of FRESH, a Novel In-Silico
High-throughput Screening Program Part II: Monocarbonyl Curcumin
Analogues: Heterocyclic Pleiotropic Kinase Inhibitors that Mediate
Anticancer Properties Part III: Development of 2nd Generation
NAMFIS Software Program by Java
3 de 8
Computational Studies of Ligand Protein Interactions Part I: TheT-Taxol Conformation Part II: Elucidating Interdependent BindingSites on Tubulin
4 de 8
Validation of Receptor-Based Drug Design and Applications in the
Study of IKKs, Truncated Taxane and LRH-1
5 de 8
Screening, hit expansion and mechanistic studies for natural
product analogs derived from traditional herbal medicine: curcumin
and triptolide.
6 de 8
Use of Receptor-Based Drug Design and Applications in the Study
of finding antagonists for MD-2/TLR4, GLP and CXCR4
7 de 8
Paclitaxel and Cyclostreptin in theTubulin Binding Site
8 de 8