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Advancing novel ligand-based cellular therapies for the treatment of pediatric acute myeloid leukemia
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Proteomic and transcriptomic signatures of microglia-derived extracellular vesicles and extension into in vivo systems.
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Identifying HELZ as a Novel DNA Double-Strand Break Repair Protein
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Astrocyte Primary Cilia are Dynamic during Development
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Investigating the Impact of Soat1 Knock-Out on Visceral Adipose Tissue Regulatory T-Cell Accumulation in TCR Transgenic Mice.
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Small-Molecule Tools to Probe and Modulate RNA Function
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Proteomic profiling of neuronal and microglial cells using TurboID in inflammatory and homeostatic states for extension into in vivo systems.
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MERTK inhibition selectively activates a DC – T-cell axis to provide anti-leukemia immunity
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The Yes-Associated Protein (YAP) promotes resistance to anti-GD2 immunotherapy in neuroblastoma through downregulation of ST8SIA1
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The development and functional testing of cellular therapies against protein tyrosine kinase 7 (PTK7) to treat high-risk neuroblastoma
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Local ecdysone synthesis in a wounded epithelium sustains developmental delay and promotes regeneration in Drosophila
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Intoxicating Interactions: The Impacts of Chronic Alcohol Use and SARS-CoV-2 Infection on Airway Epithelial Cells
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Ectopic transcription due to inappropriately inherited histone methylation may interfere with the ongoing function of terminally differentiated cells
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Investigating the Role for Y-Box Binding Protein 1 in Medulloblastoma Radiation Resistance and Post-transcriptional Regulation of Migration and Metastasis
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The Mitochondrial Electron Transport Chain Regulates Expression and Secretion of the Lipoprotein APOE
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Succinyl-CoA ligase ADP-forming subunit beta promotes stress granule assembly to regulate redox and drive cancer metastasis
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The Effect of Two Experimental Treatments (R13 & Compound 11) on Sensory Axon Regeneration After Peripheral Nerve Injury
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Investigating the role of SAMHD1 in response to Camptothecin and Sacituzumab Govitecan in triple-negative breast cancer cell line MDA-MB-231
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Impact of cytokines/chemokines on epigenetic modifications in immune cells isolated from healthy Down syndrome individuals
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Opto-Chemogenetic Modulation of Astrocytic Buffering for Re-Establishing Neuronal Homeostasis
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Analysis of Factors Required for Centrocortin mRNA Localization to Centrosomes in Drosophila Embryos
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The loss of H3T45 phosphorylation enhances histone deacetylase (HDAC) recruitment to histone H3 in hormone receptor-positive, PI3K-activated breast cancer
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The Role of Sox7 on the WNT Signaling Pathway in Lung Adenocarcinoma
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Evolution of Centromeric Protein Coding Genes in the Mus Genus
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A Taxonomic Approach to Understanding Diet-Induced Changes in Mouse Fecal and Ileal Immunoglobulin A (IgA) Concentrations
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Analyzing the localization of LSD1 in Tau transfected HEK293 cells: a novel method for exploring biological mechanisms of tauopathy and potential therapeutics
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Structural interactions of human respiratory syncytial virus NS2 with human innate immune system receptors RIG-I and MDA5
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Localization of mRNAs to Centrosomes Requires the Pericentriolar Material Scaffold
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Understanding drivers of doxorubicin resistance in Atypical Teratoid Rhabdoid Tumor
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In Vitro Expansion of Murine γδ T Cells and Transfection of Human γδ T cells for CAR T Cell Therapy
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Characterization of HIV-1 antisense RNA and enhanced transcription with interference of LEDGF/p75-directed integration
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Characterization of Cultured Human Erythrocytes Derived from BMI-1 Transduced Erythroblasts: Towards an Alternate Blood Supply
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Medulloblastoma Circulating Tumor Cell Clusters as a Novel Tumor Biomarker and Mechanism for Hematogenous Spread
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Evaluating Efficacy of CD26+ CAR T Cells in an Orthotopic, Immunocompetent Mouse Model of Pancreatic Ductal Adenocarcinoma
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Developing a Method for Circulating Tumor Cell Detection in Pediatric Medulloblastoma: Correlations with Metastatic Status and Prognostic Factors
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The Role of Fibro/Adipogenic Progenitors for Tongue Muscle Remodeling by High-Fat Diet
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YB-1 Promotes PLXND1 mRNA Translation to Mediate Tumor Migration in Sonic Hedgehog Medulloblastoma
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Effects of Phosphate Uptake/Metabolism on Behavior of Lung Cancer Cells
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Investigation of mitochondrial fusion-mediated T cell expansion and persistence for cancer immunotherapy applications
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Development and characterization of synthetic modulators of nuclear receptor LRH-1: Driving divergent signaling using a common molecular scaffold
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Imatinib mesylate as a host directed therapeutic for mycobacterial infection
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Differential regulation of Peroxisome Proliferator Activating Receptors (PPARs) via host and microbial derived processes
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Roles for Bile Transporters in the Pathogenesis and Treatment of Liver and Intestinal Diseases
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CD8 T cell Activation In Cancer Is Comprised Of Two Distinct Phases
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MEK inhibition mediates immunomodulatory factors and cell populations in advanced biliary tract cancer
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Understanding and Optimizing Gamma-Delta T cells as a Platform for Cellular Immunotherapies
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Delineating How Aging- and Obesity-Associated Chronic Inflammation Impacts B-cell Acute Lymphoblastic Leukemia Progression
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Regulation of Leukocyte Inflammation by Small Particles Including Extracellular Vesicles and Viruses
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Translational studies of neutrophils, macrophages, and T cells in the human lung: implications for cystic fibrosis and other chronic respiratory pathologies
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Characterization of cell death in Casp3-deficient mouse embryonic fibroblasts
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Viral Determinants of Reliance on Multiple Infection in Influenza A Viruses
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The role of Drosophila CPEB protein, Orb2, during asymmetric neural stem cell division
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Box C/D snoRNP assembly factors regulate translation and contribute to disease
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Statistical Modeling of C-kit+ Progenitor Cell Extracellular Vesicles to Predict Clinical Trial Outcomes
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Mitochondrial deficiencies influence variable penetrance of nuclear Nab3 granule accumulation
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THE CHAPERONE UNC-45 HAS A CRUCIAL ROLE IN MAINTAINING THE STRUCTURE AND FUNCTION OF THE MUSCLE CONTRACTILE APPARATUS DURING AGING
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Vasoactive Intestinal Peptide (VIP) Regulates ZEB1 in Cancer
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Functionally-Responsive Hydrogels: from Dynamic Coloration to Biosensing
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The association of Atrial Fibrillation and Renal Biomarkers with Brain MRI Abnormalities: An investigation using Systolic Blood Pressure Intervention Trial (SPRINT) research materials
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Exploring the Regulation of cen mRNA Localization to Centrosomes
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Examining the Role of STRIPAK in the Tight Junctions of Epithelial Cells
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Establishing the optimal conditions for in vivo RNA structural probing of guanine and uracil base-pairing in yeast
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Encapsulation of Pediatric C-kit+ Cells in Left Ventricular Myocardial Extracellular Matrix Hydrogels for Enhanced Cardiac Function
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Novel humanized mice to study the prenatal versus adult immune system
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Investigating Novel SARS-CoV-2 Inhibitors: Identification of Potent SARS-CoV-2 Antiviral Compounds and Development of a Luciferase-Based Reporter Vector for Papain-Like Protease Inhibition
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GDF15 Produced by the Failing Heart is Associated with Cardiac Cachexia
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Hepatocyte Growth Factor and Hepatocyte Growth Factor Activator Release of Fibroadipogenic Progenitors in Uninjured Pharyngeal Muscles
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Bioluminescent Optogenetics to Enhance Recovery from Peripheral Nerve Injury
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Developing and Understanding Nucleic Acid Tension Sensors to Dissect Cellular Mechanosensing
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Role of Satellite Cell Secreted Vascular Endothelial Growth Factor in Promoting Angiogenesis
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The PIX-1 Signaling Pathway that Includes the Rho GEF PIX-1 and the Rho GAP RRC-1 Direct Assembly and Stability of Integrin Adhesion Complexes in Striated Muscle
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Investigating LSD1 interaction with tau aggregates by examining LSD1 in rare tauopathy cases
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Adenosine Regulates the Formation of Macrophage Extracellular Traps Through the A2a Signaling Pathway
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Defining the Maturation of Early Human Blood Antibody Secreting Cells (ASC) to Bone Marrow Long Lived Plasma Cells (LLPC)
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Chronic Alcohol Consumption Induces Alveolar Epithelial Barrier Dysfunction in vivo
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LCMT-1 is a negative regulator of inflammation and cancer-related signaling pathways
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Dynamic in vitro and in vivo protein methylation mapping using a chemoenzymatic approach
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The Drosophila RNA-binding Protein Nab2 Interacts with the Planar Cell Polarity Pathway to Regulate Neurodevelopment
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ARF Family GTPases: Unstudied Proteins and Roles in Cilia
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The Role of CD86 Trafficking and Signaling on Myeloma Survival and Proliferation
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Regulation of microRN A-124 biogenesis during human neuronal development
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The Role of Mechanosensitive KLK10 in Endothelial Biology and Atherosclerosis
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Multiplexed approaches to investigate cellular mechanisms underlying HIV-1 transcriptional competence and viral replication
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Mechanism of Transmembrane Domain Driven Desmoglein Raft Association in Desmosome Assembly
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Determining the mechanism and clinical relevance of sphingomyelinase-mediated decreases in transepithelial CFTR current in primary bronchial epithelial cells
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IRF4 controls cell fate outcomes during the initial stages of B cell differentiation
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All the small things: Utilizing a nanoparticle platform to examine apical integrin regulation of the epithelial barrier
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Information Flow in Spatially Structured Populations
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A toolbox based on DNA nanotechnology to investigate cell receptor mechanics
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Glutamine metabolism fuels de novo purine synthesis in Multiple Myeloma for DNA replication and cell proliferation
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The role of IKK Associated protein in cisplatin resistance in cervical and lung cancer
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DNA Tether Assays and Flow Testing: Increasing Reproducibility and Throughput in Single Molecule Experiments
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The Effects of Amino Acid Substitutions on MCL-1 Protein Structure and Function
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APPKO mice exhibit dysphagia symptoms separate from whole body sarcopenia
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Tumorigenic, oncogenic, and cell cycle effects of H2A/H3 oncohistone mutations explored through structural modeling and analysis in Saccharomyces cerevisiae
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Repeat size dependent-toxicity of dipeptide repeat proteins in C9orf72 ALS/FTD
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The Structural and Molecular Changes associated with Altered Homeostatic Intrinsic Plasticity in the Axon Initial Segment and Dendrites of Fmr1 KO Neurons
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Growth Differentiation Factor 15 (GDF15) Causes Cardiac Cachexia in Heart Failure
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Determining the Role of Plasma Membrane Cholesterol in Modulating ClC Channel Function
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Mapping the interaction between oligodendrocyte-enriched G protein-coupled receptor 37 and myelin-associated glycoprotein
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