Search Constraints
« Previous |
1 - 50 of 51
|
Next »
Search Results
Select an image to start the slideshow
The Design, Synthesis, and Biological Evaluation of Subunit-selective N-Methyl-D-Aspartate Receptor Potentiators
1 of 50
Part 1. Discovery of a Fluorinated Enigmol Analog with Enhanced Pharmacokinetic and Anti-Tumor Properties. Part 2. Preferential Activation of Metabotropic Glutamate Receptor 3 over Metabotropic Glutamate Receptor 2
2 of 50
Discovery and Synthesis of Next Generation Chemokine Modulators with or without Concurrent HIV Reverse Transcriptase Inhibitory Activity
3 of 50
Development of Fluorescence-based Molecular Tension Probes to Investigate Cellular Mechanical Forces
4 of 50
Part I: Measles virus entry into cells and the inhibition offusion and replicationPart II: The nature of cyclostreptin's interaction withmicrotubules
5 of 50
Part 1: Synthesis and Anti-HIV Activity of Novel CyclobutylNucleoside and Nucleotide Analogs, Part 2: Synthesis of FluorescentNucleoside Analogs, Part 3: Synthesis of Abacavir
6 of 50
Paclitaxel and Cyclostreptin in theTubulin Binding Site
7 of 50
Towards the Synthesis of Marine Polyether Triterpenes
8 of 50
Analysis of the EF24-modulated signaling pathways for thedevelopment of novel cancer combination therapies
9 of 50
Part I: Structure and Function in the NMDA Ligand Binding DomainPart II: Comparison of Paclitaxel Analogs through MolecularDynamics Simulation; Solution Conformations of Cyclic Peptides
10 of 50
Synthesis and Anti-Viral Activity of Novel 3,6-dioxa-[3.2.0]bicyclonucleoside Nucleotide Analogs
11 of 50
Part I: Synthesis of Cyclobutyl Nucleoside and NucleotideAnalogues as HIV-1 Reverse Transcriptase InhibitorsPart II: Improvement of Glycosylation Regioselectivity in PurineNucleoside Analogue SynthesisPart III: Enantioselective Synthesis ofβ-D-Dioxolane-T andβ-D-FDOC
12 of 50
Metal Mediated Cross-Coupling Reactions for Carbon-Carbon andCarbon-Nitrogen Bonds Formation under Neutral pH Conditions
13 of 50
Synthesis of Altromycin and Kidamycin Aglycones from a Common Intermediate & Studies towards the Total Synthesis of Kidamycin
14 of 50
Part I: Conformational Analysis of Bioactive Molecules inSolutionPart II: Structure-Based Design of Selective Inhibitors ofCyclin-Dependent Kinase 7
15 of 50
Computational Studies of Ligand Protein Interactions Part I: TheT-Taxol Conformation Part II: Elucidating Interdependent BindingSites on Tubulin
16 of 50
Synthesis of Those Sectors of Saccharomicin A and B ContainingSaccharosamine and the Discovery of a Novel 4-H-1,3-OxazineSynthesis
17 of 50
Part 1: Stereoselective Synthesis of Quaternary Center BearingAzetines and β-Amino Acid Derivatives. Part 2: Natural andEnantiomeric Progesterone Analogues for the Treatment of TraumaticBrain Injury
18 of 50
Synthesis and Characterization of Unusal Amphiphiles Part I. Nonsteroidal Facial Amphiphiles Part II. Diketopiperazine Derived Surfactants
19 of 50
Engineering The Substrate Specificity Of Human Deoxycytidine Kinase
20 of 50
Part I: Design, Synthesis and Biological Evaluation of C6-C8 Bridged Epothilone AnalogsPart II: Discovery of Small Molecule CXCR4 Antagonists
21 of 50
Use of Furans as Vehicles for Heterocyclic Synthesis: Anaza-Achmatowicz Approach to Piperidine Alkaloids, a Novel OxidativeRoute to Acyloxypyrrolinones, and IMDAF Studies Toward a Synthesisof Minfiensine and Morphine
22 of 50
Multi-mechanism antiretroviral approach targeting macrophage
derived viral sanctuaries
23 of 50
SYNTHESIS OF SMALL MOLECULE THERAPEUTICS UTILIZING RHODIUM
CARBENOID CHEMISTRY
24 of 50
Part I. Design of a novel class of reversible non-covalent small
molecule inhibitors for human Granzyme B (hGrB)
Part II. Curcumin and mimics as proteasome inhibitors
Part III. Design of novel coactivator binding inhibitors (CBIs)
for the estrogen receptor α : break the 1µM barrier
25 of 50
Towards the Development of Non-Toxic Therapeutics in the Fight
Against Cancer
26 of 50
Computer-Assisted Drug Discovery Part I: Design, Development,
Validation and Application of FRESH, a Novel In-Silico
High-throughput Screening Program Part II: Monocarbonyl Curcumin
Analogues: Heterocyclic Pleiotropic Kinase Inhibitors that Mediate
Anticancer Properties Part III: Development of 2nd Generation
NAMFIS Software Program by Java
27 of 50
Design, Synthesis and Biological Evaluation of C4-C9 Bridged
Epothilone Analogs
28 of 50
Navigating the Roads to Drug Discovery: Part 1: Design, Synthesis,
and Biological Evaluation of a Novel Class of Allosteric Modulators
of N-Methyl-D-Aspartate Receptor Function Part 2: Discovery of
Novel Tetrahydroisoquinoline (THIQ)-Based CXCR4 Antagonists and
Conformational Analysis of Structurally Similar CXCR4 Antagonists
29 of 50
Generating designer enzymes for therapeutic and industrial
applications
30 of 50
Design, Synthesis, and Biological Evaluation of Subunit-Selective
N-Methyl-D-Aspartate Receptor Modulators
31 of 50
Design, Synthesis, and Biologic Evaluation of
Tetrahydroisoquinoline-Based CXCR4 Modulators
32 of 50
Organometallic Enantiomeric Scaffolds in the Synthesis of
Alkaloids: I. Homo-SN2´-like Reaction/Annulative Demetallation
and the Application in the Synthesis of (+)-Isofebrifugine II.
Uncatalyzed Electrophilic C-C Bond Forming Reactions of Pyranyl and
Pyridinyl Molybdenum Complexes
33 of 50
ASYMMETRIC REACTIONS OF DONOR/ACCEPTOR RHODIUM CARBENOIDS: FROM
FORMAL CYCLOADDITIONS TO C-H INSERTION
34 of 50
Structural Determinants of Activity, Mechanism and Structure
Activity Relationships of Novel GluN2C/D Subunit Selective
Antagonists of the N-methyl-D-Aspartate Receptor
35 of 50
Design, Synthesis, and Biological Evaluation of Subunit-Selective
N-Methyl-D-Aspartate Receptor Antagonists
36 of 50
Rhodium Alkenylcarbenes: Novel Reactivity and Precursors
37 of 50
Inhibition of the NF-κB signaling pathway by the curcumin
analogs, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31) and
3,5-Bis(2-pyridinylmethylidene)-1-methyl-4-piperidone (UBS109):
in-vitro and in-vivo studies.
38 of 50
Validation of Receptor-Based Drug Design and Applications in the
Study of IKKs, Truncated Taxane and LRH-1
39 of 50
SYNTHESIS OF CYCLOPROPANES AND DIHYDROFURANS BY METAL CARBENOID
REACTIONS
40 of 50
Development of Monocarbonyl Curcumin Analogues Towards Treating
Tuberculosis and Cancer
41 of 50
Screening, hit expansion and mechanistic studies for natural
product analogs derived from traditional herbal medicine: curcumin
and triptolide.
42 of 50
Use of Receptor-Based Drug Design and Applications in the Study
of finding antagonists for MD-2/TLR4, GLP and CXCR4
43 of 50
Investigation of C-H Bond Oxidation Reactions: I. Asymmetric
Amination of C-H Bonds Using Ruthenium(II) Catalysts II.
Investigation of Structural Determinants of Monoamine Oxidase B
44 of 50
Synthesis of 2'-Fluoro-2',3'-Dideoxynucleosides as Inhibitors of
Hepatitis C Virus RNA-Dependent RNA Polymerase; Synthesis of
Cyclobutyl Phosphonate and Phosphoramidate Prodrugs for Inhibition
of HIV Reverse Transcriptase
45 of 50
Chapter 1: The development of a model system for the B-ring of
brevenal and methods for the formation of seven-membered rings.
Chapter 2: Iterative alkyne-epoxide cross-couplings toward the
total synthesis of PM toxin A. Chapter 3: The development of
synthons for 1,3-dimethylallylation of aldehydes.
46 of 50
Development of a Copper Catalyzed Aminoacetoxylation Reaction of
Olefins, Development of an Intermolecular and Diastereoselective
Iminium Cascade Reaction and Studies Towards the Synthesis of a
Malagasy Alkaloid
47 of 50
Part I: Synthesis of Cyclobutyl
Nucleoside Analogs That Mimic AZT for Inhibition of the K65R HIV-1
Reverse Transcriptase Mutant
Part II: Synthesis and Evaluation of
Truncated Triptolide Analogs to Suppress Chronic Inflammation
48 of 50
Expanding the Scope of Donor/Acceptor Carbenes and the Synthesis of
Novel Therapeutic Agents for Cocaine Abuse
49 of 50
Design, Synthesis, and Biological Evaluation of Subunit
Selective N-Methyl-D-Aspartate Receptor Modulators
50 of 50