Directed Evolution and Computational Design of Nucleoside Analog Kinases

14N electron spin echo envelope modulation Spectroscopy of Cu(II)-imidazole coordination structure in the amyloid- beta protein of Alzheimer's disease and in model Amyloid-beta peptides and complexes

Amyloid Conformational Diversity Accessed By Truncations of a Native Protein Fold

Degradation of pesticides in food and beverages: Implications for risk assessment

Creation of Tubular α− Helical Assemblies Through Seven-Helix Coiled Coils

Part I: Synthesis of Cyclobutyl Nucleoside Analogs That Mimic AZT for Inhibition of the K65R HIV-1 Reverse Transcriptase Mutant Part II: Synthesis and Evaluation of Truncated Triptolide Analogs to Suppress Chronic Inflammation

Regulation and Characterization of Amyloid Architectures: Insight into Amyloid Cytotoxicity and Molecular Self-Assembly

Enzyme Engineering

Nanoscale Tools to Expand the Biophysical Understanding of Epidermal Growth Factor Receptor Function

From Aptamer to Riboswitch: High-throughput Screens and Selections for the Identification and Creation of Synthetic Riboswitches

Conformational evolution in amyloid self-assembly

Design, Synthesis, and Biologic Evaluation of Tetrahydroisoquinoline-Based CXCR4 Modulators

Advanced Time-Resolved Fluorescence Microscopy Techniques for the Investigation of Peptide Self-Assembly

Development of redox-active pincer ligands for Co(II) that display base-dependent nuclearity

Semagenesis in Nonparasitic Plants

Deoxy-Amine Nucleoside Polymers (dANPs) to Control Gene Expression

Generating designer enzymes for therapeutic and industrial applications

THE BROAD-HOST-RANGE PATHOGENESIS OF AGROBACTERIUM TUMEFACIENS: SUCCESSFUL COUPLING THE MOTIONS AND DOMAIN INTERACTIONS WITHIN VIRA TO INTEGRATE SIGNAL SENSING

An Approach to Generate Ultra-Robust and Highly Modular Molecular Tension Probes and Thermo-Responsive Enzymatic Nanoreactors to Regulate Reaction Rate

Amyloid: Merging the Properties of Membranes and Enzymes

Towards the Development of Non-Toxic Therapeutics in the Fight Against Cancer

Genetic Engineering of Auxotrophic Saccharomyces boulardii Mutants for Antigen Expression

Engineering Asymmetric Peptide Membranes

Conformational Exchange: A Common Mechanism for Amyloid Assembly

I: Expanding Genetic Code in S. cevevisiae with an Orthogonal tRNATrp/UCA/ Tryptophanyl tRNA Synthetase Pair II: Synthetic Yeast Prions based on a Non-NQ-rich Amyloidogenic Sequence Derived from the NAC Protein Sequence of α-Synuclein.

Protein-based Tension Probes: From Mapping Integrin Adhesion Forces to the Mechanopharmacology of Smooth Muscle Cells

Part I. Design of a novel class of reversible non-covalent small molecule inhibitors for human Granzyme B (hGrB) Part II. Curcumin and mimics as proteasome inhibitors Part III. Design of novel coactivator binding inhibitors (CBIs) for the estrogen receptor α : break the 1µM barrier

MUTUALISM IN NUCLEIC ACID/PEPTIDE DOMAIN ARRAYS: IMPLICATIONS FOR ORIGINS OF LIFE, NANOTECHNOLOGY, AND DISEASE

COMPARING AND CONTRASTING TWO PLANT PATHOGENS PROVIDE A UNIQUE WINDOW INTO THE DIFFERENCES IN THE INNATE IMMUNE RESPONSES BETWEEN DICOTS AND MONOCOTS

Signal Perception and Transmission through the VirA/VirG Two-Component System in Agrobacterium Tumefaciens

Modulating Amyloid Peptide Self-Assembly With Nucleobase Incorporation

Studies on the Activation Mechanism and Identification of aSubstrate for Giant Kinases in C. elegans Muscle

Encapsulation of Small Molecules in Peptide Nanotubes

Expression and Functional Characterization of Monoamine Oxidasefrom the Zebrafish (Danio Rerio): Comparisons with HumanMonoamine Oxidases A and B

Multidisciplinary Assessments of the Structure and Function ofCo-enzyme B12-Dependent Enzyme EthanolamineAmmonia-lyase

Analytical Methods for Pesticides in Food and ResidentialDust

Biosynthesis and Characterization of Biodegradable Materials Based on Elastin Mimetic Polypeptide

The Design of Theophylline Sensing Riboswitches in Agrobacteriumtumefaciens and Their Application in Reprogramming theVirA/VirG Two-Component System

Generation of Novel Yeast Prions through Domain Substitutions of Saccharomyces cerevisiae Sup35p

Biological Engineering with Chemical-Sensing MacromolecularSwitches: I. Discovery and Applications of Small-Molecule DependentSynthetic Riboswitches II. A Genetic Toolbox for CreatingReversible Ca 2+ -Sensitive Biomaterials

Engineering Control of Gene Expression in Bacteria Using RNA-Small Molecule Interactions

Part I: Structure and Function in the NMDA Ligand Binding DomainPart II: Comparison of Paclitaxel Analogs through MolecularDynamics Simulation; Solution Conformations of Cyclic Peptides

Exploring the peptide nanotube formation from the self-assembly of the Aβ(13-21)K16A peptide in the presence of Zinc ions

Energetic Contribution of Amyloid Self-assembly

Semagenesis & Xenognosis: Translating the Molecular Dialogues of Host-Parasite Interactions

Photolabeling of the Human Dopamine Transporter and theReactivity of Aryl Azides with Amino Acid Analogs

A Type-II Thymidine Kinase from Thermotoga maritima: KineticCharacterization, Substrate Binding, and Oligomerization

Biomaterials Design: Creation of a novel orthogonal translationalsystem in E. coli for the site-specific incorporation ofproline analogues in biosynthetic protein materials

Paclitaxel and Cyclostreptin in theTubulin Binding Site

Part I: Measles virus entry into cells and the inhibition offusion and replicationPart II: The nature of cyclostreptin's interaction withmicrotubules

Self-assembly of porousa-helical nanosheets

Re-Inventing Template-Directed Replication in Dynamic Chemical Networks

Cross-ß Folds of Amyloid as a Versatile Self-Propagating Catalyst

Control of Amyloid Beta Peptide Self-Assembly

Fundamental properties and applications of surface confined enzymes in gene regulation and molecular motors

Heterogeneity in fast-folding beta proteins

Development of Fluorescence-based Molecular Tension Probes to Investigate Cellular Mechanical Forces

Understanding Synthetic Riboswitch Mechanism and Creating Predictive Biophysical Model for Designing Novel Synthetic Riboswitches

Part 1. Discovery of a Fluorinated Enigmol Analog with Enhanced Pharmacokinetic and Anti-Tumor Properties. Part 2. Preferential Activation of Metabotropic Glutamate Receptor 3 over Metabotropic Glutamate Receptor 2

The Design, Synthesis, and Biological Evaluation of Subunit-selective N-Methyl-D-Aspartate Receptor Potentiators

Metastable Phases Direct Polymer Emergence and Evolution in Dynamic Chemical Networks

Targeting TIM-3 to reverse immune exhaustion during chronic viral infection

Synthesis of Diphenylalanine-based Peptide Aldehydes and their Self-Assembly Propensity in a Dynamic Combinatorial Library

Metabolism of CD4+ Th1 and Th2 cells

From Amyloid to Copper Arrays: The design of a functional Metalloamyloid Nanostructure (MAN)

Prion Delivery via Peptide-Nucleic Acid Co-assembly: the Inside-out Virus

Double transformation of Medicago truncatula and analysis of biotin ligase production in root cells: towards the creation of a mycorrhiza-induced INTACT system

Platelet Clearance and Mechanosensation via GPIb-IX-V: How Platelets Use the Force

Salt Effects on Peptide-Phosphate Co-Assemblies

Protein and Solvent Dynamical Contributions to Reactions of the 2-Aminopropanol Substrate Radical in Ethanolamine Ammonia-Lyase

Amplification of amyloid-beta strains and their connection to tau in Alzheimer’s Disease

EXTENDING THE CENTRAL DOGMA: DEVELOPING NOVEL INFORMATIONAL BIOPOLYMERS

An Investigation of the domain-domain interactions of A Disintegrin Metalloproteinase domain-containing protein 10 (ADAM10)

Design of a Collagen-Mimetic Peptide for Dynamic Template-Directed Polymerization

Investigation of the Germline Functions of CFP-1 and MRG-1 in Caenorhabditis elegans

Assay Development and Compound Screening to Treat Pompe Disease

Liver GALT Activity Mediated by AAV8 Gene Therapy

Morphology Engineering: Uncovering the Supramolecular Codes for Chirality