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Liotta, Dennis C, Emory University
删除限定条件 Committee: Liotta, Dennis C, Emory University
Committee
Lynn, David, Emory University
删除限定条件 Committee: Lynn, David, Emory University
Degree
PhD
删除限定条件 Degree: PhD
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Part I. Design of a novel class of reversible non-covalent small
molecule inhibitors for human Granzyme B (hGrB)
Part II. Curcumin and mimics as proteasome inhibitors
Part III. Design of novel coactivator binding inhibitors (CBIs)
for the estrogen receptor α : break the 1µM barrier
1 of 10
Towards the Development of Non-Toxic Therapeutics in the Fight
Against Cancer
2 of 10
Generating designer enzymes for therapeutic and industrial
applications
3 of 10
Development of Fluorescence-based Molecular Tension Probes to Investigate Cellular Mechanical Forces
4 of 10
Design, Synthesis, and Biologic Evaluation of
Tetrahydroisoquinoline-Based CXCR4 Modulators
5 of 10
Part I: Structure and Function in the NMDA Ligand Binding DomainPart II: Comparison of Paclitaxel Analogs through MolecularDynamics Simulation; Solution Conformations of Cyclic Peptides
6 of 10
Part 1. Discovery of a Fluorinated Enigmol Analog with Enhanced Pharmacokinetic and Anti-Tumor Properties. Part 2. Preferential Activation of Metabotropic Glutamate Receptor 3 over Metabotropic Glutamate Receptor 2
7 of 10
Part I: Synthesis of Cyclobutyl
Nucleoside Analogs That Mimic AZT for Inhibition of the K65R HIV-1
Reverse Transcriptase Mutant
Part II: Synthesis and Evaluation of
Truncated Triptolide Analogs to Suppress Chronic Inflammation
8 of 10
The Design, Synthesis, and Biological Evaluation of Subunit-selective N-Methyl-D-Aspartate Receptor Potentiators
9 of 10
Part I: Measles virus entry into cells and the inhibition offusion and replicationPart II: The nature of cyclostreptin's interaction withmicrotubules
10 of 10